https://scholars.lib.ntu.edu.tw/handle/123456789/538664
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang C.-H. | en_US |
dc.contributor.author | Wu K.-H. | en_US |
dc.contributor.author | YUNG-LI YANG | en_US |
dc.contributor.author | Peng C.-T. | en_US |
dc.contributor.author | Wang R.-F. | en_US |
dc.contributor.author | Tsai C.-W. | en_US |
dc.contributor.author | Tsai R.-Y. | en_US |
dc.contributor.author | Linn D.-T. | en_US |
dc.contributor.author | Tsai F.-J. | en_US |
dc.contributor.author | Bau D.-T. | en_US |
dc.date.accessioned | 2021-01-06T03:39:11Z | - |
dc.date.available | 2021-01-06T03:39:11Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958604385&partnerID=40&md5=3bdd833724ef3e0dc7de4b4686915d0b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/538664 | - |
dc.description.abstract | Aim: The relationship between COX-2 gene and childhood leukemia risk is ambiguous. In this study, the association of genotypic polymorphisms in cyclooxygenase 2 (Cox-2) with childhood leukemia were investigated. Materials and Methods: A total of 266 patients with childhood leukemia and 266 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped by PCR-RFLP method. Six polymorphic variants of Cox-2 were investigated, including G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, and the associations of specific genotypes with susceptibility to childhood leukemia were analysed. Results: The data showed that although there was no difference in the distribution for each genotype of Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, between the childhood leukemia and control groups (p>0.05), the analysis of combined effect for COX-2 G-765C and intron 6 showed that individuals with GC at G-765C and GG or AG+AA at intron 6 present a slightly higher potential for developing childhood leukemia than other groups. Conclusion: These findings suggest that the C allele of COX-2 G-765C may be responsible for childhood leukemia and may be useful in early detection of child leukemia. | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.ispartof | Anticancer Research | - |
dc.subject | Childhood leukemia; Cox-2; Polymorphism | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cyclooxygenase 2; cyclooxygenase 2; acute lymphoblastic leukemia; article; child; childhood leukemia; controlled study; female; genetic association; genotype; human; intron; major clinical study; male; preschool child; priority journal; school child; single nucleotide polymorphism; Taiwan; acute lymphoblastic leukemia; genetic predisposition; genetics; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; Child; Cyclooxygenase 2; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Taiwan | - |
dc.title | Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 20944149 | - |
dc.identifier.scopus | 2-s2.0-77958604385 | - |
dc.relation.pages | 3649-3653 | - |
dc.relation.journalvolume | 30 | - |
dc.relation.journalissue | 9 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-3598-7218 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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