https://scholars.lib.ntu.edu.tw/handle/123456789/539944
標題: | Hepatitis B virus infection, its sequelae, and prevention by vaccination | 作者: | LI-MIN HUANG CHUN-YI LU Chen D.-S. |
公開日期: | 2011 | 卷: | 23 | 期: | 2 | 起(迄)頁: | 237-243 | 來源出版物: | Current Opinion in Immunology | 摘要: | Hepatitis B virus (HBV) infection is a global health problem. There are >350 million of people chronically infected with this virus worldwide. Hepatitis B vaccines are effective in preventing the infection. Humoral immunity is the key factor in conferring the protection. Hepatitis B surface antibody titers of ?10. mIU/mL are protective. Chronic carriage of HBV is related to the age when the infection occurs, the younger the age the higher the chronicity rate. Hence, vaccination should be given in early childhood. People vaccinated in infancy have a protection of >20 years, and hepatocellular carcinoma decreases in them. Although the vaccine-conferred immunity wanes by time, a universal booster is not recommended at present. ? 2010 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953123163&doi=10.1016%2fj.coi.2010.12.013&partnerID=40&md5=151d38cf481c000a6b0666a272b2ec6a https://scholars.lib.ntu.edu.tw/handle/123456789/539944 |
ISSN: | 0952-7915 | DOI: | 10.1016/j.coi.2010.12.013 | SDG/關鍵字: | gamma interferon; hepatitis B vaccine; hepatitis B(e) antigen; tumor necrosis factor alpha; adaptive immunity; antibody response; antibody titer; CD8+ T lymphocyte; cellular immunity; drug efficacy; drug safety; environmental exposure; genetic polymorphism; hepatitis B; human; humoral immunity; innate immunity; liver cell carcinoma; natural killer cell; review; seroconversion; Th1 cell; vaccination; virus load; virus replication; Carcinoma, Hepatocellular; Hepatitis B; Hepatitis B Vaccines; Humans; Immunity, Humoral; Liver Neoplasms |
顯示於: | 醫學系 |
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