https://scholars.lib.ntu.edu.tw/handle/123456789/539946
Title: | Immunogenicity and reactogenicity of DTPa-IPV/Hib vaccine Co-administered with hepatitis B vaccine for primary and booster vaccination of Taiwanese infants | Authors: | PEI-LAN SHAO CHUN-YI LU Hsieh Y.-C. Bock H.L. LI-MIN HUANG |
Issue Date: | 2011 | Publisher: | Elsevier B.V. | Journal Volume: | 110 | Journal Issue: | 6 | Start page/Pages: | 415-422 | Source: | Journal of the Formosan Medical Association | Abstract: | Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib) conjugate vaccine (DTPa-IPV/Hib, Infanrix?-IPV + Hib) was assessed when co-administered with hepatitis B (HBV) vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15-18 months, and HBV at birth, 1.5, 6 and 15-18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs) rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort. ? 2011 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960379689&doi=10.1016%2fS0929-6646%2811%2960061-2&partnerID=40&md5=c2513634362cb50ff9df8796e170b36d https://scholars.lib.ntu.edu.tw/handle/123456789/539946 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(11)60061-2 | SDG/Keyword: | diphtheria pertussis poliomyelitis tetanus vaccine; diphtheria pertussis tetanus vaccine; Haemophilus influenzae type b vaccine; hepatitis B vaccine; recombinant hepatitis B vaccine; anorexia; antibody titer; article; child; diphtheria; drowsiness; drug tolerability; fever; Haemophilus infection; Haemophilus influenzae type b; human; human experiment; immunogenicity; infant; irritability; normal human; pain; pertussis; poliomyelitis; preschool child; serology; side effect; skin redness; swelling; tetanus; vaccination [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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