https://scholars.lib.ntu.edu.tw/handle/123456789/539946
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | PEI-LAN SHAO | en_US |
dc.contributor.author | CHUN-YI LU | en_US |
dc.contributor.author | Hsieh Y.-C. | en_US |
dc.contributor.author | Bock H.L. | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.creator | Shao P.-L.;Chun-Yi Lu;Hsieh Y.-C.;Bock H.L.;Huang L.-M. | - |
dc.date.accessioned | 2021-01-08T02:16:18Z | - |
dc.date.available | 2021-01-08T02:16:18Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960379689&doi=10.1016%2fS0929-6646%2811%2960061-2&partnerID=40&md5=c2513634362cb50ff9df8796e170b36d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/539946 | - |
dc.description.abstract | Immunogenicity and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (Hib) conjugate vaccine (DTPa-IPV/Hib, Infanrix?-IPV + Hib) was assessed when co-administered with hepatitis B (HBV) vaccine. Seventy healthy infants received DTPa-IPV/Hib at 1.5, 3.5, 6 and 15-18 months, and HBV at birth, 1.5, 6 and 15-18 months of age. Serological responses were assessed. Diphtheria, tetanus, Hib and pertussis seroprotection/seropositivity rates were 100% after primary vaccination. Post-primary immune responses to poliovirus could not be evaluated for technical reasons. However, after the booster dose, seroprotection/seropositivity rates, including poliovirus, were 100%. Over 95% were seroprotected against HBV. Post-booster geometric mean antibody concentrations/titers (GMC/GMTs) rose from 14-fold to 45-fold, indicating effective priming against all antigens, including polioviruses. DTPa-IPV/Hib was well tolerated alone or co-administered with HBV. No serious adverse events were considered related to vaccination. Primary and booster vaccination with combined DTPa-IPV/Hib and HBV was immunogenic and well tolerated. Combination vaccines enable vaccine providers to conveniently provide routine pediatric immunizations, with minimal discomfort. ? 2011 Elsevier & Formosan Medical Association. | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | diphtheria pertussis poliomyelitis tetanus vaccine; diphtheria pertussis tetanus vaccine; Haemophilus influenzae type b vaccine; hepatitis B vaccine; recombinant hepatitis B vaccine; anorexia; antibody titer; article; child; diphtheria; drowsiness; drug tolerability; fever; Haemophilus infection; Haemophilus influenzae type b; human; human experiment; immunogenicity; infant; irritability; normal human; pain; pertussis; poliomyelitis; preschool child; serology; side effect; skin redness; swelling; tetanus; vaccination | - |
dc.title | Immunogenicity and reactogenicity of DTPa-IPV/Hib vaccine Co-administered with hepatitis B vaccine for primary and booster vaccination of Taiwanese infants | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0929-6646(11)60061-2 | - |
dc.identifier.scopus | 2-s2.0-79960379689 | - |
dc.relation.pages | 415-422 | - |
dc.relation.journalvolume | 110 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine-NTUHHC | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0003-3334-1330 | - |
crisitem.author.orcid | 0000-0002-5240-2808 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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