https://scholars.lib.ntu.edu.tw/handle/123456789/540039
標題: | Comparison of once daily cefpodoxime proxetil suspension and thrice daily cefaclor suspension in the treatment of acute otitis media in children. | 作者: | Tsai H.-Y. LI-MIN HUANG Chiu H.-H. PO-REN HSUEH PING-ING LEE CHUN-YI LU Chiu T.-F. Lin H.-C. CHIN-YUN LEE |
公開日期: | 1998 | 卷: | 31 | 期: | 3 | 起(迄)頁: | 165-170 | 來源出版物: | Journal of microbiology, immunology, and infection | 摘要: | An open-labeled and randomized trial was conducted to compare the efficacy and safety of once daily cefpodoxime proxetil suspension (10mg/kg/day) and thrice daily cefaclor (45mg/kg/day) in the treatment of acute otitis media in children. A total of 57 children aged from 6 months to 9 years were enrolled; 23 were treated with cefpodoxime and 34 with cefaclor. Satisfactory clinical outcome, either cure or improvement, was achieved at the end of treatment in 90% of patients in the cefaclor group and 95% of patients in the cefpodoxime group (p > 0.05). Clinical recurrence was identified at the follow-up visits in one case of the cefaclor group (3%), and none in the cefpodoxime group (p > 0.05). These drugs were well tolerated by 14/21 (67%) in the cefpodoxime-treated group and 27/32 (84%) in the cefaclor-treated group. The incidence of adverse events was slightly higher in the cefpodoxime group than in the cefaclor group, however the difference did not reach statistical significance (p > 0.05). The daily cost of once-daily cefpodoxime was lower than that of thrice-daily cefaclor. We conclude that cefpodoxime administered once daily is as effective and safe as cefaclor administered thrice daily in the treatment of acute otitis media in children. The less dosing frequency and lower daily price of cefpodoxime provide additional benefits. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032149648&partnerID=40&md5=d3f21e65e6911bc5dd82787d8c4fcd30 https://scholars.lib.ntu.edu.tw/handle/123456789/540039 |
ISSN: | 1684-1182 | SDG/關鍵字: | cefaclor; cefpodoxime proxetil; ceftizoxime; cephalosporin derivative; drug derivative; acute disease; article; child; clinical trial; comparative study; controlled clinical trial; controlled study; drug administration; female; human; infant; male; otitis media; preschool child; randomized controlled trial; suspension; Acute Disease; Cefaclor; Ceftizoxime; Cephalosporins; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Otitis Media; Suspensions |
顯示於: | 醫學系 |
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