https://scholars.lib.ntu.edu.tw/handle/123456789/540122
標題: | Role of serum dehydroepiandrosterone sulfate level on the clearance of chronic hepatitis B virus infection | 作者: | JIA-FENG WU Tsai W.-Y. YI-CHING TUNG HUEY-LING CHEN YEN-HSUAN NI HONG-YUAN HSU MEI-HWEI CHANG |
公開日期: | 2014 | 出版社: | Springer-Verlag Tokyo | 卷: | 49 | 期: | 5 | 起(迄)頁: | 900-906 | 來源出版物: | Journal of Gastroenterology | 摘要: | Background: The natural course of chronic hepatitis B virus (HBV) infection and relevant host factors remain unclear. This study aims to investigate the impact of dehydroepiandrosterone sulfate (DHEAS) on the clearance of chronic HBV infection. Methods: Two hundred and one hepatitis B e antigen (HBeAg)-positive chronic HBV-infected children (101 females) were recruited. Serum DHEAS levels were determined in all subjects at 15 years of age. Serum alanine aminotransferase (ALT) levels, DHEAS levels, HBV seromarkers, genotypes, and viral loads were included for analysis. Results: Subjects with serum DHEAS levels >3.6 μmol/L at midpuberty had earlier HBeAg seroconversion (median age, 14.7 vs. 18.2 years; HR, 1.9; P = 0.03), and the impact persisted even after adjusting for gender, HBV genotype, peak ALT levels, and viral load. Subjects with DHEAS levels >3.6 μmol/L at 15 years of age had more HBV viral titers decrement from 15 to 20 years of age (mean ± SD, 3.5 ± 2.5 vs. 1.2 ± 2.2 log10 copies/mL; P = 0.05) and shorter duration for HBeAg seroconversion than others (mean ± SD, 5.6 ± 4.4 vs. 9.2 ± 4.9 years; P = 0.02). Higher serum DHEAS levels at 15 years of age are also associated with greater hepatitis B surface antigen (HBsAg) titer decrement from 15 to 20 years of age (correlation coefficient = 0.45, P = 0.04). Conclusions: Higher serum DHEAS levels at midpuberty predicts more HBV viral load and HBsAg titer decrement from midpuberty to young adulthood. Higher serum DHEAS levels at midpuberty also correlate with younger age of spontaneous HBeAg seroconversion in chronic genotype B and C HBV-infected patients. ? 2013 Springer. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901440204&doi=10.1007%2fs00535-013-0831-0&partnerID=40&md5=ca32bed905a471d33ec7fcfb4c22b99b https://scholars.lib.ntu.edu.tw/handle/123456789/540122 |
ISSN: | 0944-1174 | DOI: | 10.1007/s00535-013-0831-0 | SDG/關鍵字: | alanine aminotransferase; hepatitis B core antibody; hepatitis B core antigen; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B(e) antibody; hepatitis B(e) antigen; prasterone sulfate; alanine aminotransferase; hepatitis B surface antigen; hepatitis B(e) antigen; prasterone sulfate; adolescent; adult; alanine aminotransferase blood level; androgen blood level; antibody titer; article; blood sampling; cohort analysis; female; follow up; genotype; hepatitis B; Hepatitis B virus; human; major clinical study; male; priority journal; prospective study; radioimmunoassay; seroconversion; serology; survival time; viral clearance; virus load; age; blood; child; genetics; hepatitis B; infant; isolation and purification; preschool child; puberty; virology; young adult; Adolescent; Adult; Age Factors; Alanine Transaminase; Child; Child, Preschool; Cohort Studies; Dehydroepiandrosterone Sulfate; Female; Follow-Up Studies; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Male; Prospective Studies; Puberty; Viral Load; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。