https://scholars.lib.ntu.edu.tw/handle/123456789/540610
標題: | Metabolic profiles and fibrosis of nonalcoholic fatty liver disease in the elderly: A community-based study | 作者: | Chen T.-P. Lai M. Lin W.-Y. KUO-CHIN HUANG KUEN-CHEH YANG |
關鍵字: | advanced fibrosis; elderly; metabolic syndrome; non?alcoholic fatty liver disease | 公開日期: | 2020 | 出版社: | Blackwell Publishing | 卷: | 35 | 期: | 9 | 起(迄)頁: | 1636-1643 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aims: There are sparse data on the epidemiology of fatty liver in the elderly Asian population. We evaluated for predictors of fatty liver and high risk of advanced fibrosis in a community-based elderly population. Methods: A total of 1091 participants (mean age was 74.6?±?6.3?years) were enrolled from 2017 to 2018. Subjects with age younger than 65?years, alcoholism, and history of hepatitis B and hepatitis C were excluded. Fatty liver was diagnosed with abdominal ultrasound by using ultrasonographic fatty liver indicator, a semi-quantitative measurement grading the severity (normal, mild, and moderate-to-severe). Fibrosis-4 score was used for the prediction of the high risk of advanced fibrosis. Using a multivariable logistic regression model, we identified predictors of fatty liver and high risk of advanced fibrosis. Results: In this ambulatory elderly Asian population, the prevalence of fatty liver is 41.9% and of high risk of advanced fibrosis is 12.3%. The prevalence of fatty liver decreases (44.5% to 31.8%), and the high risk of advanced fibrosis increases (3.9% to 27.0%) with aging significantly (both P?0.05). Metabolic syndrome is a risk factor for fatty liver (odds ratio [OR], 3.19; 95% CI, 2.41–4.22) but not for high risk of advanced fibrosis (OR, 0.67; 95% CI, 0.41–1.08). Hypertriglyceridemia decreases the risk for high risk of advanced fibrosis (OR, 0.53; 95% CI, 0.33–0.87). Conclusion: Fatty liver is prevalent in the ambulatory elderly Asian population, affecting over 40% of this population. Age is a risk factor for high risk of advanced fibrosis, with the disease likely progressing from a steatotic to a fibrotic picture with age. ? 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085082515&doi=10.1111%2fjgh.15073&partnerID=40&md5=7361c131334f897a6a929fff49c501a1 https://scholars.lib.ntu.edu.tw/handle/123456789/540610 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.15073 | SDG/關鍵字: | aged; aging; Article; Asian; disease severity assessment; echography; female; fibrosis 4 score; high risk patient; human; hypertriglyceridemia; liver fibrosis; major clinical study; male; metabolic syndrome X; metabolism; nonalcoholic fatty liver; population; prediction; prevalence; priority journal; quantitative analysis; risk assessment; scoring system; age; Asian continental ancestry group; complication; diagnostic imaging; fibrosis; liver; liver cirrhosis; modem; nonalcoholic fatty liver; pathology; risk factor; very elderly; Age Factors; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Female; Fibrosis; Humans; Hypertriglyceridemia; Liver; Liver Cirrhosis; Male; Metabolic Syndrome; Modems; Non-alcoholic Fatty Liver Disease; Prevalence; Risk Factors; Ultrasonography |
顯示於: | 醫學系 |
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