https://scholars.lib.ntu.edu.tw/handle/123456789/540611
標題: | Elevated Red Cell Distribution Width Is Independently Associated With a Higher Frailty Risk Among 2,932 Community-Dwelling Older Adults | 作者: | Li C.-M. CHIA-TER CHAO Chen S.-I. DER-SHENG HAN KUO-CHIN HUANG COhort of GEriatric Nephrology in NTUH (COGENT) study group |
公開日期: | 2020 | 出版社: | Frontiers Media S.A. | 卷: | 7 | 起(迄)頁: | 470 | 來源出版物: | Frontiers in Medicine | 摘要: | Background: Older adults are at an increased risk of frailty, but laboratory surrogates for identifying frailty in this population remain controversial and clinicians frequently encounter difficulty during frailty screening. We examined whether having a high red cell distribution width (RDW) was associated with an increased probability of frailty in older adults. Methods: We prospectively included community-dwelling older adults between 2013 and 2016 from a single institute, with their clinical features/laboratory parameters documented. We used the Study of Osteoporotic Fractures index (malnutrition, poor physical performance, and fatigue) to delineate frailty, and harnessed multiple logistic regression to investigate whether having a high RDW (? 15.7%) was associated with an increased risk of having frailty among these participants. Results: A total of 2,932 older adults (mean 73.5 ± 6.7 years; 44.6% male) were included, among whom 113 (3.9%) and 76 (2.6%) had a high RDW and presented frailty, respectively. Older adults with a high RDW were more likely to be frail (p = 0.002) and had more positive SOF items than those with normal RDW levels (p = 0.013). Those with a high RDW exhibited a significantly higher risk of having frailty (odds ratio [OR] 2.689, 95% confidence interval [CI] 1.184–6.109) compared to those without. Sensitivity analyses using RDW as a continuous variable similarly showed that RDW levels were positively associated with frailty risk (OR 1.223 per 1% RDW higher). Conclusions: In older adults, higher RDW can be regarded as a frailty indicator, and the readiness in RDW assessment supports its screening utility. ? Copyright ? 2020 Li, Chao, Chen, Han and Huang. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090588042&doi=10.3389%2ffmed.2020.00470&partnerID=40&md5=9a211001cb661f0539347668e35ca8b6 https://scholars.lib.ntu.edu.tw/handle/123456789/540611 |
ISSN: | 2296-858X | DOI: | 10.3389/fmed.2020.00470 | SDG/關鍵字: | albumin; creatinine; globulin; age; aged; albumin blood level; Article; body weight; clinical feature; community dwelling person; creatinine blood level; diabetes mellitus; drinking behavior; erythrocyte count; fatigue; female; frailty; heart disease; human; hyperlipidemia; hypertension; leukocyte count; major clinical study; male; malnutrition; physical performance; platelet count; prospective study; pulse rate; red blood cell distribution width; sensitivity analysis; smoking; waist circumference |
顯示於: | 醫學系 |
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