https://scholars.lib.ntu.edu.tw/handle/123456789/540633
標題: | Increased risk for major depressive disorder in severely obese patients after bariatric surgery — a 12-year nationwide cohort study | 作者: | CHIA-WEN LU Chang Y.-K. YI-HSUAN LEE Kuo C.-S. HAO-HSIANG CHANG Huang C.-T. Hsu C.-C. KUO-CHIN HUANG |
公開日期: | 2018 | 出版社: | Taylor and Francis Ltd | 卷: | 50 | 期: | 7 | 起(迄)頁: | 605-612 | 來源出版物: | Annals of Medicine | 摘要: | Background: Bariatric surgery is associated with a significant improvement in depressive mood in the initial postoperative years, but the maintenance of the improvement is under debate. Aim: To explore the association between bariatric surgery and major depressive disorder (MDD) in a 12-year nationwide cohort study. Method: Using the National Health Insurance Research Database of Taiwan, we identified 2302 patients who underwent bariatric surgery in 2001–2009. These patients were matched by propensity score to 6493 obese patients who did not receive bariatric surgery. We followed the surgical and control cohorts until death, any diagnosis of MDD or 31 December 2012. We used Cox proportional hazard regression models to calculate the relative risk of MDD in those who received bariatric surgery. Results: Overall, there was a 1.70-fold (95% CI: 1.27–2.27) higher risk of MDD in the surgical group. Subjects receiving malabsorptive procedures showed a higher risk of MDD (3.01, 95% CI: 1.78–5.09) than those receiving restrictive procedures (1.51, 95% CI: 1.10–2.07). Stratified by follow-up period, there was a higher risk of MDD in the surgical group (2.92, 95% CI: 1.75–4.88) than in the restrictive group four years after bariatric surgery. Conclusions: Bariatric surgery was significantly associated with an elevated risk of MDD.KEY MESSAGES Bariatric surgery is associated with a significant improvement in depressive mood in the initial postoperative years, but the improvement is not maintained. Less is known about the relationship between bariatric surgery and risk of major depressive disorder. This was the first nationwide cohort study which found that bariatric surgery was significantly associated with an elevated risk of MDD (aHR: 1.70; CI: 1.27–2.27), mainly with malabsorptive procedures (aHR: 3.01; CI: 1.78–5.09) and at time points more than four years after surgery (aHR: 2.92; CI: 1.75–4.88) compared with the risk in matched controls. These findings imply an association between long-term malabsorption and the postoperative incidence of MDD. Long-term malabsorption might be related to the incidence of major depressive disorder after bariatric surgery. The possible causal relationship between nutritional deficiency after bariatric surgery and major depressive disorder warrants further investigation. ? 2018, ? 2018 Informa UK Limited, trading as Taylor & Francis Group. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053332169&doi=10.1080%2f07853890.2018.1511917&partnerID=40&md5=152d2648d520c0336c7c6470e25224ba https://scholars.lib.ntu.edu.tw/handle/123456789/540633 |
ISSN: | 0785-3890 | DOI: | 10.1080/07853890.2018.1511917 | SDG/關鍵字: | antidepressant agent; adult; Article; bariatric surgery; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease risk assessment; female; follow up; groups by age; human; hypertension; major clinical study; major depression; malabsorption; male; morbid obesity; obese patient; outcome assessment; priority journal; propensity score; proportional hazards model; risk factor; surgical patient; Taiwan; adolescent; adverse event; aged; bariatric surgery; incidence; major depression; malabsorption; middle aged; morbid obesity; postoperative complication; postoperative period; prevalence; psychology; risk assessment; time factor; young adult; Adolescent; Adult; Aged; Bariatric Surgery; Depressive Disorder, Major; Female; Follow-Up Studies; Humans; Incidence; Malabsorption Syndromes; Male; Middle Aged; Obesity, Morbid; Postoperative Complications; Postoperative Period; Prevalence; Risk Assessment; Risk Factors; Taiwan; Time Factors; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。