https://scholars.lib.ntu.edu.tw/handle/123456789/540662
Title: | The Relationship of Diabetes and Smoking Status to Hepatocellular Carcinoma Mortality | Authors: | CHIEN-HSIEH CHIANG CHIA-WEN LU Han H.-C. Hung S.-H. YI-HSUAN LEE KUEN-CHEH YANG KUO-CHIN HUANG |
Issue Date: | 2016 | Publisher: | Lippincott Williams and Wilkins | Journal Volume: | 95 | Journal Issue: | 6 | Start page/Pages: | e2699 | Source: | Medicine (United States) | Abstract: | The relationship of diabetes and smoking status to hepatocellular carcinoma (HCC) mortality is not clear. We aimed to investigate the association of smoking cessation relative to diabetes status with subsequent deaths from HCC. We followed up 51,164 participants (aged 44-94 years) without chronic hepatitis B or C from 1 January 1998 to 31 December 2008 enrolled from nationwide health screening units in a prospective cohort study. The primary outcomes were deaths from HCC. During the study period, there were 253 deaths from HCC. History of diabetes was associated with deaths from HCC for both total participants (adjusted hazard ratio [HR], 2.97; 95% confidence interval [CI], 2.08-4.23) and ever smokers with current or past smoking habits (HR, 1.92; 95% CI, 1.10-3.34). Both never smokers (HR, 0.46; 95% CI, 0.32-0.65) and quitters (HR, 0.62; 95% CI, 0.39-0.97) had a lower adjusted risk of HCC deaths compared with current smokers. Among all ever smokers with current or past smoking habits, as compared with diabetic smokers, only quitters without diabetes had a lower adjusted risk of HCC deaths (HR, 0.37; 95% CI, 0.18-0.78). However, quitters with diabetes were observed to have a similar risk of deaths from HCC when compared with smokers with diabetes. Regarding the interaction between diabetes and smoking status on adjusted HCC-related deaths, with the exception of quitters without history of diabetes, all groups had significantly higher HRs than nondiabetic never smokers. There was also a significant multiplicative interaction between diabetes and smoking status on risk of dying from HCC (P=0.033). We suggest clinicians should promote diabetes prevention and never smoking to associate with reduced subsequent HCC mortality even in adults without chronic viral hepatitis. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958260566&doi=10.1097%2fMD.0000000000002699&partnerID=40&md5=54c5ffb34a7c957aed2163ac2423ff95 https://scholars.lib.ntu.edu.tw/handle/123456789/540662 |
ISSN: | 0025-7974 | DOI: | 10.1097/MD.0000000000002699 | SDG/Keyword: | high density lipoprotein cholesterol; triacylglycerol; adult; aged; alcohol consumption; Article; body mass; cancer mortality; cholesterol blood level; cohort analysis; controlled study; diabetes mellitus; disease association; fatty liver; female; follow up; human; hypercholesterolemia; hypertension; hypertriglyceridemia; liver cell carcinoma; major clinical study; male; obesity; physical activity; priority journal; prospective study; risk factor; risk reduction; smoking; smoking cessation; smoking habit; adverse effects; complication; diabetic complication; liver cell carcinoma; liver tumor; middle aged; mortality; smoking; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Diabetes Complications; Female; Humans; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Smoking; Smoking Cessation |
Appears in Collections: | 醫學系 |
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