https://scholars.lib.ntu.edu.tw/handle/123456789/540721
標題: | Elevated serum dehydroepiandrosterone sulphate level correlates with increased risk for metabolic syndrome in the elderly men | 作者: | Chen Y.C. HAO-HSIANG CHANG Chiung-Jung Wen Lin W.Y. Chen C.Y. Hong B.S. KUO-CHIN HUANG |
公開日期: | 2010 | 卷: | 40 | 期: | 3 | 起(迄)頁: | 220-225 | 來源出版物: | European Journal of Clinical Investigation | 摘要: | Background The previous studies regarding the association between endogenous dehydroepiandrosterone (DHEA) sulphate level and metabolic syndrome are inconsistent. This study aimed to investigate such relationship in elderly Taiwanese men. Materials and methods Five hundred and eighty-five elderly Taiwanese men (mean age 68·7 ± 8·3 years) were enrolled as the baseline cohort population in 2000. In addition to a questionnaire, body mass index (BMI), blood pressure, fasting blood glucose, lipids, albumin and serum DHEA-S levels were measured for each participant. Metabolic syndrome was based on the definition by the America Heart Association/National Heart Lung Blood Institute. Results The prevalence of metabolic syndrome was 33·3%. Using multivariate logistic regression analyses with adjustments for age, smoking, alcohol, physical activities, albumin and BMI, there was a positive relationship between serum DHEA-S level and metabolic syndrome. The highest DHEA-S quartile group had increased risk for metabolic syndrome (odds ratio = 2·68, 95% confidence interval: 1·44-5·01, P < 0·01) compared with the lowest quartile group. The mean serum DHEA-S level increased with increasing number of metabolic syndrome components. Conclusions The prevalence of metabolic syndrome increases with elevated DHEA-S levels among elderly Taiwanese men. Thus, elevated serum DHEA-S level should be treated as an important risk factor for metabolic syndrome in elderly men. ? 2009 Stichting European Society for Clinical Investigation Journal Foundation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77649211752&doi=10.1111%2fj.1365-2362.2009.02248.x&partnerID=40&md5=7a6462b5c6e7c8b835ffa4215e81f156 https://scholars.lib.ntu.edu.tw/handle/123456789/540721 |
ISSN: | 0014-2972 | DOI: | 10.1111/j.1365-2362.2009.02248.x | SDG/關鍵字: | albumin; glucose; high density lipoprotein cholesterol; lipid; prasterone sulfate; triacylglycerol; adult; aged; alcohol consumption; article; blood pressure; body mass; cigarette smoking; controlled study; glucose blood level; human; major clinical study; male; metabolic syndrome X; obesity; physical activity; priority journal; structured questionnaire; Taiwan; Aged; Biological Markers; Dehydroepiandrosterone Sulfate; Humans; Logistic Models; Male; Metabolic Syndrome X; Middle Aged; Prevalence; Risk; Taiwan |
顯示於: | 醫學系 |
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