https://scholars.lib.ntu.edu.tw/handle/123456789/540858
標題: | Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity | 作者: | Wu C.-H. SONG-CHOU HSIEH KO-JEN LI Lu M.-C. CHIA-LI YU |
公開日期: | 2007 | 卷: | 16 | 期: | 4 | 起(迄)頁: | 265-272 | 來源出版物: | Lupus | 摘要: | We investigated whether premature telomeric loss occurred in peripheral polymorphonuclear neutrophils (PMN) as well as mononuclear cells (MNC) from patients with systemic lupus erythematosus (SLE). We measured the telomere length of MNC and PMN in 60 SLE patients and 26 sex-, race- and age-matched healthy volunteers by Southern blotting with chemiluminescence method. The possible predisposing factors associated with telomere change were also analysed. We found the telomere length of MNC and PMN shortened with age in different degrees in both SLE and control groups. Compared to the control group, the telomere length was shortened in both SLE-MNC (6.08 kb in SLE versus 6.71 kb in control, P = 0.0008) and PMN (6.24 kb in SLE versus 6.75 kb in control, P = 0.0025). The average reduction in telomere length in SLE patients was equivalent to a premature senescence of 16.5 years in MNC and 13.4 years in PMN. In addition, the accelerated telomere shortening was more prominent in SLE patients younger than 45 years old. SLE disease activity (SLEDAI) contributed remarkably to the accelerated telomere erosion, at least in PMN. Moreover, the telomere length of MNC was significantly shorter than PMN in the same SLE patients with leukopenia and lymphopenia. These data suggested that MNC and PMN from patients with SLE displayed premature and accelerated telomere shortening that SLE is an independent factor for it. ? 2007 SAGE Publications. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249011458&doi=10.1177%2f0961203307077155&partnerID=40&md5=0cee79d7b9b5b0caf0d6c6dfd106018d https://scholars.lib.ntu.edu.tw/handle/123456789/540858 |
ISSN: | 0961-2033 | DOI: | 10.1177/0961203307077155 | SDG/關鍵字: | genomic DNA; telomerase; adolescent; adult; aged; article; chemoluminescence; controlled study; disease activity; enzyme activity; human; leukopenia; lymphocytopenia; major clinical study; neutrophil; polymorphonuclear cell; priority journal; Southern blotting; systemic lupus erythematosus; T lymphocyte; telomere; Adolescent; Adult; Aged; Case-Control Studies; Female; Humans; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Male; Neutrophils; Severity of Illness Index; Sickness Impact Profile; Telomerase; Telomere |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。