https://scholars.lib.ntu.edu.tw/handle/123456789/541044
標題: | Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on asian diagnostic criteria | 作者: | Kamisawa T. Kim M.-H. WEI-CHIH LIAO Liu Q. Balakrishnan V. Okazaki K. Shimosegawa T. Chung J.B. Lee K.T. HSIU-PO WANG TSUNG-CHUN LEE Choudhuri G. |
公開日期: | 2011 | 卷: | 40 | 期: | 2 | 起(迄)頁: | 200-205 | 來源出版物: | Pancreas | 摘要: | OBJECTIVES: To clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) in Asia. METHODS: A retrospective, actual situation survey of AIP diagnosed by Asian criteria was conducted in 10 centers of Japan, Korea, Taiwan, China, and India. RESULTS: A total of 327 AIP cases (258 male and 69 female subjects; average age, 60.0 years) were enrolled. Obstructive jaundice was the most frequent initial symptom (46%-74%), followed by weight loss (4%-51%) and abdominal pain (19%-44%). Diffuse swelling of the pancreas was frequent in Japan (64%) and Korea (81%), but segmental swelling of the pancreas was more frequent in Taiwan (70%) and China (72%) (P < 0.01). Serum immunoglobulin G4 levels were elevated in 58%-100% of cases in Japan, Korea, and Taiwan. Pathologically, almost all AIPs in Asia were lymphoplasmacytic sclerosing pancreatitis. Sclerosing cholangitis was the most frequent extrapancreatic lesion (60%-81%). Steroid therapy was a major and effective therapeutic strategy in Japan, Korea, and Taiwan. However, the rate of resection or bypass operation was higher in Taiwan (40%) and China (72%) (P < 0.01). CONCLUSIONS: Features of AIP are fundamentally similar in Japan, Korea, Taiwan, and China. Knowledge of emerging AIP should be more widespread in Asia to avoid unnecessary operation. ? 2011 Lippincott Williams & Wilkins, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951722064&doi=10.1097%2fMPA.0b013e3181fab696&partnerID=40&md5=e28f4209fec846eef59f72f5d107371c https://scholars.lib.ntu.edu.tw/handle/123456789/541044 |
ISSN: | 0885-3177 | DOI: | 10.1097/MPA.0b013e3181fab696 | SDG/關鍵字: | antinuclear antibody; immunoglobulin G4; prednisolone; rheumatoid factor; abdominal pain; abdominal swelling; adult; aged; antibody detection; article; Asian; autoimmune pancreatitis; China; chronic diarrhea; clinical assessment; clinical feature; comorbidity; computer assisted tomography; controlled study; diabetes mellitus; disease exacerbation; dyspepsia; fatigue; female; health survey; histopathology; human; immunoglobulin blood level; immunopathogenesis; India; Japan; Korea; major clinical study; male; nausea; obstructive jaundice; pancreas resection; pathophysiology; priority journal; prognosis; retrospective study; salivary gland swelling; sclerosing cholangitis; sex ratio; steroid therapy; swelling; symptom; Taiwan; weight reduction; Asia; Asian Continental Ancestry Group; Autoantibodies; Autoimmune Diseases; Biological Markers; Biopsy; Female; Health Status Indicators; Humans; Immunoglobulin G; Male; Middle Aged; Pancreatectomy; Pancreatitis; Predictive Value of Tests; Retrospective Studies; Steroids; Tomography, X-Ray Computed; Treatment Outcome |
顯示於: | 醫學系 |
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