https://scholars.lib.ntu.edu.tw/handle/123456789/541147
標題: | Influence of cytochrome P450 2C19 genetic polymorphism and dosage of rabeprazole on accuracy of proton-pump inhibitor testing in Chinese patients with gastroesophageal reflux disease | 作者: | YI-CHIA LEE Lin J.-T. HSIU-PO WANG HAN-MO CHIU MING-SHIANG WU |
公開日期: | 2007 | 出版社: | Blackwell Publishing | 卷: | 22 | 期: | 8 | 起(迄)頁: | 1286-1292 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aim: To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P450 (CYP) 2C19 polymorphism in a population with a high prevalence of people who metabolize PPI poorly. Methods: In this randomized, open-label trial, patients with symptoms suggestive of GERD were randomized to receive a 2-week test with 20- or 40-mg rabeprazole after diagnostic endoscopy. Symptom response was assessed with a four-grade daily record; in addition, DNA from peripheral blood leukocytes was genotyped for CYP2C19 polymorphism with the polymerase chain reaction-restriction fragment length polymorphism technique. Results: Of the 164 patients who completed the study, 69 (42.1%) were endoscopically positive for esophagitis; the remaining 95 (57.9%) were diagnosed with endoscopy-negative reflux disease. Based on the best cut-off value for 50% symptom reduction, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for detecting erosive esophagitis were 68%, 70%, 66%, 72%, and 69%, respectively, for the 20-mg regimen, and 84%, 71%, 64%, 88%, and 76%, respectively, for the 40-mg regimen, a non-significant difference. Regarding the genotype, 60 (39%) patients had two wild-type alleles, 63 (40.9%) had one variant allele, and 31 (20.1%) had two variant CYP2C19 alleles. The presence of a variant allele did not alter the diagnostic efficacy of PPI testing. Conclusions: Both dose levels of rabeprazole proved efficacious in the diagnosis of GERD. Various measures of test accuracy were unrelated to the status of the CYP2C19 genotype. ? 2007 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547672651&doi=10.1111%2fj.1440-1746.2007.04942.x&partnerID=40&md5=ee583a91927be91b96f5f59043b00387 https://scholars.lib.ntu.edu.tw/handle/123456789/541147 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2007.04942.x | SDG/關鍵字: | cytochrome P450 2C19; DNA; rabeprazole; adult; article; Chinese; clinical trial; controlled clinical trial; controlled study; diagnostic accuracy; diagnostic value; dizziness; drug efficacy; drug withdrawal; endoscopy; esophagitis; female; gastroesophageal reflux; genetic polymorphism; genotype; human; leukocyte; male; pharmacogenetics; polymerase chain reaction; predictive validity; prevalence; priority journal; randomization; randomized controlled trial; reflux esophagitis; restriction fragment length polymorphism; wild type |
顯示於: | 醫學系 |
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