https://scholars.lib.ntu.edu.tw/handle/123456789/541333
Title: | Impact of smoking cessation on clinical outcomes in patients with head and neck squamous cell carcinoma receiving curative chemoradiotherapy: A prospective study | Authors: | JENNY LING-YU CHEN Shen C.-W. CHIA-CHUN WANG YU-SEN HUANG JO-PAI CHEN CHIEN-HSIEH CHIANG Lin Y.-L. SUNG-HSIN KUO CHUN-WEI WANG |
Issue Date: | 2019 | Publisher: | John Wiley and Sons Inc. | Journal Volume: | 41 | Journal Issue: | 9 | Start page/Pages: | 3201-3210 | Source: | Head and Neck | Abstract: | Background: We hypothesized that patients with head and neck squamous cell carcinoma (HNSCC) with smoking cessation during curative chemoradiotherapy (CRT) had fewer complications and lower tumor progression risks. Methods: Sixty-three patients with nonmetastatic HNSCC who were smokers at diagnosis (carbon monoxide [CO] breath concentrations ?3 ppm) and underwent curative CRT were prospectively enrolled. Successful smoking cessation throughout CRT was confirmed by CO breath concentrations <3 ppm at CRT completion. Results: Forty-one patients (65%) successfully discontinued smoking throughout CRT. With a median 33-month follow-up, patients with successful smoking cessation during CRT had significantly fewer, greater, and lower probabilities of grade ?3 acute toxicities (P =.01), progression-free survival (P =.03), and permanent gastrostomy or tracheostomy (P =.04), respectively, than those continuing smoking throughout CRT. In multivariate analysis, successful smoking cessation during CRT significantly reduced tumor progression risks (hazard ratio: 0.4, P =.05). Conclusion: Smoking cessation during curative CRT reduced treatment-related toxicities and tumor progression risks in patients with HNSCC. ? 2019 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066912651&doi=10.1002%2fhed.25814&partnerID=40&md5=fbbfc2ad0a661377a29618515deccdab https://scholars.lib.ntu.edu.tw/handle/123456789/541333 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.25814 | SDG/Keyword: | cisplatin; taxane derivative; UFT; acute toxicity; adult; aged; Article; bone necrosis; cancer survival; chemoradiotherapy; clinical article; clinical outcome; clinical trial; cone beam computed tomography; dermatitis; distant metastasis free survival; female; fibrosis; follow up; gastrostomy; head and neck squamous cell carcinoma; human; infection; intensity modulated radiation therapy; male; mucosa inflammation; overall survival; priority journal; progression free survival; prospective study; radiation dose fractionation; radiotherapy dosage; risk reduction; smoking cessation; smoking cessation program; soft tissue disease; tracheostomy; trismus; tumor growth; adverse event; disease exacerbation; head and neck tumor; middle aged; multivariate analysis; prognosis; survival analysis; treatment outcome; Adult; Aged; Chemoradiotherapy; Disease Progression; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Prospective Studies; Smoking Cessation; Squamous Cell Carcinoma of Head and Neck; Survival Analysis; Treatment Outcome |
Appears in Collections: | 醫學系 |
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