https://scholars.lib.ntu.edu.tw/handle/123456789/541333
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JENNY LING-YU CHEN | en_US |
dc.contributor.author | Shen C.-W. | en_US |
dc.contributor.author | CHIA-CHUN WANG | en_US |
dc.contributor.author | YU-SEN HUANG | en_US |
dc.contributor.author | JO-PAI CHEN | en_US |
dc.contributor.author | CHIEN-HSIEH CHIANG | en_US |
dc.contributor.author | Lin Y.-L. | en_US |
dc.contributor.author | SUNG-HSIN KUO | en_US |
dc.contributor.author | CHUN-WEI WANG | en_US |
dc.date.accessioned | 2021-01-15T05:29:32Z | - |
dc.date.available | 2021-01-15T05:29:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066912651&doi=10.1002%2fhed.25814&partnerID=40&md5=fbbfc2ad0a661377a29618515deccdab | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/541333 | - |
dc.description.abstract | Background: We hypothesized that patients with head and neck squamous cell carcinoma (HNSCC) with smoking cessation during curative chemoradiotherapy (CRT) had fewer complications and lower tumor progression risks. Methods: Sixty-three patients with nonmetastatic HNSCC who were smokers at diagnosis (carbon monoxide [CO] breath concentrations ?3 ppm) and underwent curative CRT were prospectively enrolled. Successful smoking cessation throughout CRT was confirmed by CO breath concentrations <3 ppm at CRT completion. Results: Forty-one patients (65%) successfully discontinued smoking throughout CRT. With a median 33-month follow-up, patients with successful smoking cessation during CRT had significantly fewer, greater, and lower probabilities of grade ?3 acute toxicities (P =.01), progression-free survival (P =.03), and permanent gastrostomy or tracheostomy (P =.04), respectively, than those continuing smoking throughout CRT. In multivariate analysis, successful smoking cessation during CRT significantly reduced tumor progression risks (hazard ratio: 0.4, P =.05). Conclusion: Smoking cessation during curative CRT reduced treatment-related toxicities and tumor progression risks in patients with HNSCC. ? 2019 Wiley Periodicals, Inc. | - |
dc.publisher | John Wiley and Sons Inc. | - |
dc.relation.ispartof | Head and Neck | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cisplatin; taxane derivative; UFT; acute toxicity; adult; aged; Article; bone necrosis; cancer survival; chemoradiotherapy; clinical article; clinical outcome; clinical trial; cone beam computed tomography; dermatitis; distant metastasis free survival; female; fibrosis; follow up; gastrostomy; head and neck squamous cell carcinoma; human; infection; intensity modulated radiation therapy; male; mucosa inflammation; overall survival; priority journal; progression free survival; prospective study; radiation dose fractionation; radiotherapy dosage; risk reduction; smoking cessation; smoking cessation program; soft tissue disease; tracheostomy; trismus; tumor growth; adverse event; disease exacerbation; head and neck tumor; middle aged; multivariate analysis; prognosis; survival analysis; treatment outcome; Adult; Aged; Chemoradiotherapy; Disease Progression; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Prospective Studies; Smoking Cessation; Squamous Cell Carcinoma of Head and Neck; Survival Analysis; Treatment Outcome | - |
dc.title | Impact of smoking cessation on clinical outcomes in patients with head and neck squamous cell carcinoma receiving curative chemoradiotherapy: A prospective study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/hed.25814 | - |
dc.identifier.pmid | 31116482 | - |
dc.identifier.scopus | 2-s2.0-85066912651 | - |
dc.relation.pages | 3201-3210 | - |
dc.relation.journalvolume | 41 | - |
dc.relation.journalissue | 9 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Oncology-NTUHYL | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Radiation Oncology-NTUCC | - |
crisitem.author.dept | Division of Radiation Oncology | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0001-8553-8069 | - |
crisitem.author.orcid | 0000-0003-4262-8712 | - |
crisitem.author.orcid | 0000-0003-0894-4498 | - |
crisitem.author.orcid | 0000-0003-0054-887X | - |
crisitem.author.orcid | 0000-0002-2758-6027 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | Oncology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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