https://scholars.lib.ntu.edu.tw/handle/123456789/541724
標題: | Instantaneous frequency as a new approach for evaluating the clinical severity of Duchenne muscular dystrophy through ultrasound imaging | 作者: | WEN-CHIN WENG CHIA-WEI LIN Shen, H.-C. Chang, C.-C. CHIEN-CHENG CHANG |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 94 | 起(迄)頁: | 235-241 | 來源出版物: | Ultrasonics | 摘要: | Duchenne muscular dystrophy (DMD) results in loss of ambulation for the patients. Ultrasound attenuation correlates with fat content in muscles, resulting in changes in signal frequency. The Hilbert–Huang transform (HHT) allows time–frequency analysis with high time–frequency resolution. This study explored the feasibility of using the instantaneous frequency (IF) obtained from the HHT to diagnose the walking function of patients with DMD. Eighty-five participants (12 control and 73 patients with DMD) underwent a standard-care ultrasound examination of the gastrocnemius to acquire raw image data for ultrasound B-mode and IF calculations, which were compared with the DMD stage using Pearson correlation and receiver operating characteristic (ROC) curve analyses. With increasing DMD stage, the median IF decreased from 7.25 to 7.01 MHz (the correlation coefficient r = ?0.73; the probability value p < 0.0001). The area under the ROC curve was 0.97 when using ultrasound IF to discriminate between ambulatory and nonambulatory patients (accuracy: 91.76%; sensitivity: 93.75%; and specificity: 90.57%). The study reveals that ultrasound IF has great potential in DMD evaluation and management. ? 2018 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054057047&doi=10.1016%2fj.ultras.2018.09.004&partnerID=40&md5=d7e62b4438751832576bd3c44e3317cf https://scholars.lib.ntu.edu.tw/handle/123456789/541724 |
ISSN: | 0041-624X | DOI: | 10.1016/j.ultras.2018.09.004 | SDG/關鍵字: | Correlation methods; Mathematical transformations; Ultrasonic imaging; Ultrasonics; Ultrasonography; Area under the ROC curve; Correlation coefficient; Duchenne muscular dystrophies; Instantaneous frequency; Receiver operating characteristic curve analysis; Time frequency analysis; Ultrasound attenuation; Ultrasound frequency; Neuromuscular rehabilitation; adolescent; case control study; child; diagnostic imaging; Duchenne muscular dystrophy; echography; female; human; male; pathophysiology; physiology; preschool child; procedures; severity of illness index; skeletal muscle; walking; young adult; Adolescent; Case-Control Studies; Child; Child, Preschool; Female; Humans; Male; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Severity of Illness Index; Ultrasonography; Walking; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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