https://scholars.lib.ntu.edu.tw/handle/123456789/541915
標題: | Initial prostate biopsy of grade group one: A study of pathological upgrade and biochemical recurrence after robotic-assisted laparoscopic radical prostatectomy | 作者: | Hung F.-C. CHI-SHIN TSENG CHUNG-HSIN CHEN HONG-CHIANG CHANG CHAO-YUAN HUANG YU-CHUAN LU |
公開日期: | 2020 | 出版社: | Wolters Kluwer Medknow Publications | 卷: | 31 | 期: | 4 | 起(迄)頁: | 170-176 | 來源出版物: | Urological Science | 摘要: | Purpose: The aim of our study was to analyze the outcomes and predictive factors in patients with an initial biopsy grade group 1 (GG1) prostate cancer (PCa) at risk of GG upgrading. Materials and Methods: We performed a retrospective review of patients who had GG1 PCa at biopsy and were managed with robotic-assisted laparoscopic radical prostatectomy (RaLRP) from January 2012 to December 2018 and collected their clinical characteristics and pathological data. The primary outcomes were GG upgrading at RaLRP and biochemical recurrence-free survival (BCRFS) in these patients. The secondary outcome was to analyze the risk factors of pathological upgrades. Results: Among the 159 patients with initial prostate biopsy of GG1, 122 patients (76.7%) had GG upgrading based on the final pathology at RaLRP. Multivariable analysis showed that transrectal ultrasound (TRUS)-measured prostate volume <30 mL (odds ratio [OR] 4.727, P = 0.011), prostate-specific antigen density [PSAD] ?0.2 ng/mL2(OR 3.201, P = 0.019), magnetic resonance imaging (MRI)-measured prostate volume <30 mL (OR 3.892, P = 0.007), and PSAD ? 0.2 ng/mL2(OR 2.65, P = 0.019) were independent predictive factors of GG upgrading. During 5 years of follow-up, patients who upgraded to GG3-5 had a significantly shorter time to biochemical recurrence than those who remained as GG1 (P = 0.001) or upgraded to GG2 (P = 0.008). Conclusion: The final pathology grading was underestimated in 76.7% of initial biopsy GG1 and may influence the BCRFS after RaLRP. Prostate volume <30 mL and PSAD ?0.2 ng/mL2, measured by either MRI or TRUS, were significant predictive factors of biopsy GG1 upgrading. ? 2020 Wolters Kluwer Medknow Publications. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089534265&doi=10.4103%2fUROS.UROS_91_19&partnerID=40&md5=81873c8779afeb58b1dac36ea76a80a2 https://scholars.lib.ntu.edu.tw/handle/123456789/541915 |
ISSN: | 1879-5226 | DOI: | 10.4103/UROS.UROS_91_19 | SDG/關鍵字: | prostate specific antigen; adult; aged; Article; biochemical recurrence free survival; cancer grading; clinical feature; follow up; human; human tissue; major clinical study; male; multivariate analysis; nuclear magnetic resonance imaging; predictive value; priority journal; prostate biopsy; prostate cancer; prostate volume; retrospective study; risk factor; robot-assisted prostatectomy; transrectal ultrasonography; treatment outcome |
顯示於: | 醫學系 |
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