https://scholars.lib.ntu.edu.tw/handle/123456789/541917
標題: | Factors Associated with Bothersome Lower Urinary Tract Symptoms in Middle-Aged Men Receiving Health Checkup | 作者: | Yang T.-K. Chang C.-C. HONG-CHIANG CHANG Yang H.-J. KUO-HOW HUANG |
公開日期: | 2019 | 出版社: | Nature Publishing Group | 卷: | 9 | 期: | 1 | 起(迄)頁: | 901 | 來源出版物: | Scientific Reports | 摘要: | The prospective study is to investigate the associations between serum testosterone levels and LUTS among middle-aged men ?40 years receiving health check-up. Lower urinary tract symptoms were evaluated by the self-administered International Prostate Symptom Score questionnaire. Serum prostate specific antigen and total testosterone level were checked in all subjects. A total of 1752 men were enrolled into the study. The mean age was 55.6 ± 9.7 years. All study subjects were stratified into low, medium and high testosterone levels by two cut-off, 3.0 and 4.11 ng/mL. We found that testosterone levels were significantly associated with metabolic syndrome and body fat components. Compared to those with low testosterone levels, subjects with high and medium testosterone had a significantly higher IPSS (5.84 ± 5.55 vs 6.71 ± 5.68 and 6.34 ± 5.66, p = 0.032) and storage score (2.76 ± 2.29 vs 3.20 ± 2.49 and 2.90 ± 2.49; p = 0.009), and a more moderate/severe LUTS (IPSS ≧ 8) (26.5% vs 35.7% and 29.9%; p = 0.002). Multivariate analyses showed that high vs low testosterone levels (OR, 1.76; 95% CI, 1.26–2.45) and prostate volume ≧25 vs <25 mL (OR, 1.38; 95% CI, 1.04–1.82) significantly associated with the presence of moderate/severe LUTS. Pearson correlation analyses showed significantly positive correlations between testosterone level and IPSS in whole study sample (Pearson correlation coefficient, 0.066; p < 0.01) and in the subgroup of moderate/severe LUTS (Pearson correlation coefficient, 0.038; p < 0.05). In conclusion, high testosterone and prostate volume adversely impacted LUTS in our target population. ? 2019, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060804797&doi=10.1038%2fs41598-018-37605-4&partnerID=40&md5=6f4c170190fe265943c5da066a5cb49f https://scholars.lib.ntu.edu.tw/handle/123456789/541917 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-37605-4 | SDG/關鍵字: | biological marker; testosterone; adult; aged; blood; health survey; human; lower urinary tract symptom; male; middle aged; odds ratio; prospective study; prostate hypertrophy; questionnaire; Adult; Aged; Biomarkers; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Odds Ratio; Prospective Studies; Prostatic Hyperplasia; Public Health Surveillance; Surveys and Questionnaires; Testosterone |
顯示於: | 醫學系 |
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