https://scholars.lib.ntu.edu.tw/handle/123456789/541923
標題: | Trends in the use of antimuscarinics and alpha-adrenergic blockers in women with lower urinary tract symptoms in Taiwan: A nationwide, population-based study, 2007-2012 | 作者: | Lin Y.-H. Huang W.-Y. Chang C.-C. Chen Y.-F. Wu L.-Y. HONG-CHIANG CHANG KUO-HOW HUANG |
公開日期: | 2019 | 出版社: | Public Library of Science | 卷: | 14 | 期: | 10 | 起(迄)頁: | e0220615 | 來源出版物: | PLoS ONE | 摘要: | Background: We aim to examine the trend in the use of antimuscarinics and off-label alpha-adrenergic blockers for treatment of lower urinary tract symptoms (LUTS) in a Taiwanese Women Cohort between 2007 and 2012. Methods: This population-based National Health Insurance Research Database (NHIRD) was used to examine the trends in the use of antimuscarinics or off-label alpha-adrenergic blockers in Taiwan. A sample of 1,000,000 individuals randomly drawn from the whole population of 23 million individuals who were registered in the NHI in 2005. From 2007 through 2012, women aged over 18 years whose claim record contained prescriptions of either of the two drugs for treatment of any of the LUTS-related diagnoses were identified and analyzed. The annual usage of the two drug classes were calculated by defined daily dose (DDD). Results: From 2007-2012, there was a 0.80 fold (69676.8 to 125104.3) increase in DDD of antimuscarinics in our cohort. The overall healthcare seeking prevalence of LUTS was 7.33% in 2007 and 12.38% in 2012, in a rising trend. The prevalence of antimuscarinics-treated LUTS in our cohort increased from 2.53 in 2007 to 3.41 per 1000 women in 2012. The prevalence of LUTS treated by antimuscarinics increased especially for those older than 60 years during the study period. Conclusions: This 6-year observational study provided the epidemiologic information of clinically significant LUTS of Asian female population. Moreover, there was a rising trend in the use of antimuscarinics and off-label alpha-adrenergic blockers in the population-based cohort. ? 2019 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072966723&doi=10.1371%2fjournal.pone.0220615&partnerID=40&md5=86fe6aab40d53f44e7724d897d548ecf https://scholars.lib.ntu.edu.tw/handle/123456789/541923 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0220615 | SDG/關鍵字: | alpha adrenergic receptor blocking agent; muscarinic receptor blocking agent; alpha adrenergic receptor blocking agent; muscarinic receptor blocking agent; adult; cohort analysis; controlled study; drug efficacy; drug use; female; human; lower urinary tract symptom; major clinical study; observational study; outcome assessment; prescription; Review; Taiwan; trend study; adolescent; aged; factual database; lower urinary tract symptom; middle aged; prevalence; public health; randomized controlled trial; Taiwan; Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Databases, Factual; Female; Humans; Lower Urinary Tract Symptoms; Middle Aged; Muscarinic Antagonists; National Health Programs; Prevalence; Taiwan |
顯示於: | 醫學系 |
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