https://scholars.lib.ntu.edu.tw/handle/123456789/542084
標題: | Prognostic value of saturated prostate cryoablation for localized prostate cancer | 作者: | CHUNG-HSIN CHEN Tai Y.-S. YEONG-SHIAU PU |
公開日期: | 2015 | 出版社: | Springer Verlag | 卷: | 33 | 期: | 10 | 起(迄)頁: | 1487-1494 | 來源出版物: | World Journal of Urology | 摘要: | Purpose: To evaluate the oncological outcomes and complications of patients with saturated prostate cryoablation. Methods: A cohort of 208 patients cumulatively treated between June 2008 and December 2012 qualified for study inclusion, each undergoing total-gland cryoablation for prostate cancer. The degree of saturated prostate cryoablation was defined as the average prostate volume per cryoprobe (APVC), and divided into four groups (groups 1–4: <3?ml, 3 to <4?ml, 4 to <5?ml, ≧5?ml, respectively). Post-ablative complications were measured prospectively at weeks 1, 2, 4, 8, 12, and 24 by using the Common Terminology Criteria for Adverse Events. Biochemical failure was gauged by Phoenix criterion. The Kruskal–Wallis rank sum test and Chi-square test were used to compare clinical characteristics of therapeutic subsets. The Cox proportional hazard model was applied for comparison of recurrence risk between groups. Results: APVC group 1 had the highest pre-operative PSA value and smallest prostate size among the groups. Multivariate analysis of risks of biochemical failures revealed that the larger the APVC, the higher the hazard (p for trend =?0.01). Compared to the group 1 patients, the hazard ratios of biochemical failures in groups 2–4 were 4.4 (confidence interval (CI): 0.5–37), 8.8 (CI 1.1–73), and 9.4 (CI 1.1–78), respectively. Nevertheless, the complication rate of APVC group 1 patients was similar to the other three groups. Conclusions: Saturated prostate cryoablation by reducing APVC would be beneficial for cancer control without compromising patient safety. ? 2014, Springer-Verlag Berlin Heidelberg. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942508820&doi=10.1007%2fs00345-014-1467-2&partnerID=40&md5=ddd2a236c2b1f30a10b4461828f21f0f https://scholars.lib.ntu.edu.tw/handle/123456789/542084 |
ISSN: | 0724-4983 | DOI: | 10.1007/s00345-014-1467-2 | SDG/關鍵字: | aged; biopsy; cancer staging; cryosurgery; endoscopic ultrasonography; follow up; human; incidence; male; middle aged; mortality; Postoperative Complications; procedures; prognosis; Prostatic Neoplasms; rectum; retrospective study; survival rate; Taiwan; trends; tumor recurrence; tumor volume; very elderly; Aged; Aged, 80 and over; Biopsy; Cryosurgery; Endosonography; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Complications; Prognosis; Prostatic Neoplasms; Rectum; Retrospective Studies; Survival Rate; Taiwan; Tumor Burden |
顯示於: | 醫學系 |
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