https://scholars.lib.ntu.edu.tw/handle/123456789/542085
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Yeh T.-C. | en_US |
dc.contributor.author | Tai Y.-S. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | CHUNG-HSIN CHEN | en_US |
dc.creator | Yeh T.-C.;Tai Y.-S.;Pu Y.-S.;Chung-Hsin Chen | - |
dc.date.accessioned | 2021-01-26T03:36:49Z | - |
dc.date.available | 2021-01-26T03:36:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1879-5226 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937513959&doi=10.1016%2fj.urols.2015.05.002&partnerID=40&md5=4079b5986fe2a49aca62c61e8a9120a6 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/542085 | - |
dc.description.abstract | Objective: To investigate the clinical and pathological characteristics of arsenic-related bladder cancer. Methods: From 2008 through 2011, data on 7699 patients with bladder cancer were extracted from the Taiwan Cancer Registry Database. A diagnosis of bladder cancer (International Statistical Classification of Diseases and Related Health Problems, 9th Revision: 188) was confirmed in all patients. Using birth residency codes, patients were divided into three groups: the core zone (CZ; an arsenic endemic area with well water arsenic levels of 350-1100ng/mL); zone 1 (Z1; an area with well water arsenic levels of?350ng/mL but not a blackfoot disease-endemic area); and zone 2 (Z2; an area with well water arsenic levels of<350ng/mL). Clinicopathological characteristics and survival outcomes were compared between the three groups. Results: In this cohort, 119 (1.5%), 1145 (14.9%), and 6435 (83.6%) patients were born in the CZ, Z1, and Z2, respectively. A higher proportion of female patients (35.3%, 31.4%, and 27.5%; p=0.014) and lower smoking rates (29%, 34.8%, and 35.9%; p=0.694) were noted in the CZ compared with Z1 and Z2. CZ patients had more high-grade differentiated (80.9%, 69.9%, and 63.0%; p<0.001) and high clinical stage (stages II-IV, 52.8%, 38.1%, and 31.8%; p<0.001) tumors compared with Z1 and Z2 patients. Radical cystectomy was infrequently performed for clinical stage II (19.6%) and stage III (25.2%) bladder cancer patients. CZ patients had significantly shorter overall and cancer-specific survival durations compared with Z1 and Z2 patients. Older age, female sex, higher tumor grade or stage, and higher arsenic levels were associated with both poorer overall and cancer-specific survival in a multivariate analysis with a Cox proportional model. Conclusion: In Taiwan, patients with arsenic-related bladder cancer may have poorer tumor characteristics and decreased overall and cancer-specific survival rates. ? 2015. | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Urological Science | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | arsenic; adult; age distribution; aged; arsenic pollution; Article; bladder cancer; cancer grading; cancer radiotherapy; cancer registry; cancer staging; cancer survival; controlled study; cystectomy; environmental exposure; female; human; major clinical study; male; middle aged; overall survival; pollution; priority journal; sex ratio; smoking; survival rate; Taiwan; transurethral resection; treatment response; very elderly | - |
dc.title | Characteristics of arsenic-related bladder cancer: A study from Nationwide Cancer Registry Database in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.urols.2015.05.002 | - |
dc.identifier.scopus | 2-s2.0-84937513959 | - |
dc.relation.pages | 103-108 | - |
dc.relation.journalvolume | 26 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.orcid | 0000-0002-4921-5315 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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