https://scholars.lib.ntu.edu.tw/handle/123456789/542195
標題: | Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects | 作者: | Yang S.-H. CHIA-LI YU Chen Y.-L. Chiao S.-L. Chen M.-L. |
關鍵字: | IgE; IL-10; IL-8; Immunomodulation; Perennial allergic rhinitis; Soluble ICAM-1; Xin-yi-san | 公開日期: | 2010 | 卷: | 10 | 期: | 8 | 起(迄)頁: | 951-958 | 來源出版物: | International Immunopharmacology | 摘要: | Background: Perennial allergic rhinitis (AR) is a common health problem with a high prevalence rate of 43.6% in Taiwan. In our previous study, a mixed formula of Chinese herbs consisted of Xin-yi-san, Xiao-ging-long-tang, and Xiang-sha-liu-jun-zi-tang, exerted diverse immunomodulatory effects in the treatment of patients with perennial allergic rhinitis. Objective: The aim of the present study was to determine whether Xin-yi-san (XYS) alone is effective in the treatment of AR and tried to explore its molecular mechanism of anti-allergic activity. Methods: In a randomized double-blind study, 108 patients with AR received either XYS or a placebo for 3months. The effectiveness of XYS was evaluated by nasal symptoms, nasal airflow resistance, nostril dissection area, and serum titer of specific IgE antibodies against house dust mite allergens. In addition, the production of T helper (Th) 1 (represented by interferon-γ) and Th2 [represented by interleukin (IL)-4, IL-10, and IL-13] cytokines, the proinflammatory cytokine IL-8, soluble intercellular adhesion molecule (sICAM), and arachidonate metabolites prostagladin E2 (PGE2) and leukotriene C4 (LTC4) by polymorphonuclear neutrophils (PMNs) were compared before and after treatment between the two groups. Results: XYS attenuated nasal symptoms (sneezing and rhinorrhea) and nasal congestion through reduction of nasal airflow resistance and increase in nostril dissection areas. We also found that XYS exerted diverse immunomodulatory effects, including suppression of serum IgE levels and increased production of IL-10, sICAM-1, and IL-8 compared to placebo group. However, XYS treatment did not affect the release of PGE2 and LTC4 from PMNs. Conclusions: This study originally provides the evidence that Xin-yi-san alone is an effective herb in the treatment of perennial allergic rhinitis. ? 2010 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954957885&doi=10.1016%2fj.intimp.2010.05.008&partnerID=40&md5=1802ba30a38bde63dda6f22fa1246275 https://scholars.lib.ntu.edu.tw/handle/123456789/542195 |
ISSN: | 1567-5769 | DOI: | 10.1016/j.intimp.2010.05.008 | SDG/關鍵字: | antiallergic agent; arachidonic acid; Chinese drug; gamma interferon; house dust allergen; immunoglobulin E; interleukin 10; interleukin 13; interleukin 4; interleukin 8; leukotriene C4; prostaglandin E2; unclassified drug; xin yi san; adult; antibody titer; article; Chinese medicine; clinical effectiveness; clinical evaluation; controlled study; cytokine production; drug effect; enzyme linked immunosorbent assay; female; human; human cell; immunomodulation; major clinical study; male; molecular mechanics; nose airway resistance; nose congestion; perennial rhinitis; polymorphonuclear cell; priority journal; rhinorrhea; sneezing; Th1 cell; Adult; Animals; Antigens, Dermatophagoides; Complex Mixtures; Cytokines; Drugs, Chinese Herbal; Female; Humans; Immunoglobulin E; Immunomodulation; Male; Medicine, Chinese Traditional; Nasal Obstruction; Neutrophils; Pyroglyphidae; Rhinitis, Allergic, Perennial; Taiwan; Th1 Cells; Th2 Cells |
顯示於: | 醫學系 |
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