https://scholars.lib.ntu.edu.tw/handle/123456789/542280
標題: | A dominant human leucocyte antigen DR4-Dw15 restricted mycobacterial 65KDa antigen-specific t-cell immunity in chinese patients with rheumatoid arthritis | 作者: | Lai N.-S. Lan J.-L. CHIA-LI YU Lin R.-H. |
關鍵字: | 65 kDa heat shock protein; Class II major histocompatibility; DR4-Dwl5; Mycobacterium tuberculosis; Rheumatoid arthritis | 公開日期: | 1995 | 卷: | 34 | 期: | 6 | 起(迄)頁: | 498-506 | 來源出版物: | Rheumatology | 摘要: | The human leucocyte antigen DR4-associated immune responses to Mycobacterium tuberculosis 65 kDa heat shock protein were considered to be relevant to the pathogenesis of rheumatoid arthritis (RA). In the Chinese population, DR4-Dwl5 was found to be the predominant DR4 subtype in RA. To further define the immune responses associated with DR4-Dwl5 molecules, the proliferative responses of peripheral (PBMC and synovial mononuclear cells (SFMC) to mycobacterial 65 kDa antigen were evaluated. The SFMC of all of our RA patients responded significantly to 65 kDa mycobacterial antigen. The responses of PBMC to this antigen in RA were much lower than those of SFMC. Our results further indicated that relatively low numbers of peripheral antigen-specific T-cells, but not incompetence of peripheral antigen presenting cells, might be related to the observed low responsiveness to 65 kDa antigen in PBMC of RA patients. Of utmost importance, DR4-Dwl5 was proved to be one of the major restrictive molecules in mycobacterial 65 kDa antigen-specific immune responses in Chinese RA patients. ? 1995 British Society for Rheumatology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029087847&doi=10.1093%2frheumatology%2f34.6.498&partnerID=40&md5=4189abdc9eca5053509bfe163a2969fe https://scholars.lib.ntu.edu.tw/handle/123456789/542280 |
ISSN: | 1462-0324 | DOI: | 10.1093/rheumatology/34.6.498 | SDG/關鍵字: | HLA DR4 antigen; mycobacterium antigen; adult; article; bacterial immunity; cellular immunity; chinese; clinical article; controlled study; female; human; male; mononuclear cell; mycobacterium tuberculosis; pathogenesis; priority journal; rheumatoid arthritis; synovium; t lymphocyte; Adult; Antigens, Bacterial; Arthritis, Rheumatoid; Cell Division; Chaperonins; Epitopes; Female; HLA-D Antigens; Human; Immunity; Male; Middle Age; Mongoloid Race; Monocytes; Reference Values; Reiter Disease; Support, Non-U.S. Gov't; Synovial Fluid; T-Lymphocytes |
顯示於: | 醫學系 |
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