https://scholars.lib.ntu.edu.tw/handle/123456789/543269
標題: | A photoluminescent colorimetric probe of bovine serum albumin-stabilized gold nanoclusters for new psychoactive substances: Cathinone drugs in seized street samples | 作者: | Yen, Y.-T. Chen, T.-Y. Chen, C.-Y. Chang, C.-L. Chyueh, S.-C. Chang, H.-T. HUAN-TSUNG CHANG |
關鍵字: | Cathinone; Gold nanoclusters; New psychoactive substances; Sensor | 公開日期: | 2019 | 卷: | 19 | 期: | 16 | 起(迄)頁: | - | 來源出版物: | Sensors (Switzerland) | 摘要: | Screening of illicit drugs for new psychoactive substances—namely cathinone—at crime scenes is in high demand. A dual-emission bovine serum albumin-stabilized gold nanoclusters probe was synthesized and used for quantitation and screening of 4-chloromethcathinone and cathinone analogues in an aqueous solution. The photoluminescent (PL) color of the bovine serum albumin-stabilized Au nanoclusters (BSA-Au NCs) probe solution changed from red to dark blue during the identification of cathinone drugs when excited using a portable ultraviolet light-emitting diodes lamp (365 nm). This probe solution allows the PL color-changing point and limit of detection down to 10.0 and 0.14 mM, respectively, for 4-chloromethcathinone. The phenomenon of PL color-changing of BSA-Au NCs was attributed to its PL band at 650 nm, quenching through an electron transfer mechanism. The probe solution was highly specific to cathinone drugs, over other popular illicit drugs, including heroin, cocaine, ketamine, and methamphetamine. The practicality of this BSA-Au NCs probe was assessed by using it to screen illicit drugs seized by law enforcement o_cers. All 20 actual cases from street and smuggling samples were validated using this BSA-Au NCs probe solution and then confirmed using gas chromatography–mass spectrometry. The results reveal this BSA-Au NCs probe solution is practical for screening cathinone drugs at crime scenes. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85071491590&partnerID=40&md5=43de70751a50a494e300803abbc60cf7 https://scholars.lib.ntu.edu.tw/handle/123456789/543269 |
DOI: | 10.3390/s19163554 | SDG/關鍵字: | Amines; Color; Colorimetry; Crime; Drug products; Electron transitions; Gas chromatography; Gold; Mammals; Mass spectrometry; Probes; Sensors; Surface plasmon resonance; Bovine serum albumins; Cathinone; Colorimetric probes; Electron transfer mechanisms; Gold nanocluster; Limit of detection; New psychoactive substances; Ultraviolet light emitting diodes; Nanoclusters; alkaloid; bovine serum albumin; cathinone; nanomaterial; animal; bovine; chemistry; colorimetry; genetic procedures; human; isolation and purification; Alkaloids; Animals; Biosensing Techniques; Cattle; Colorimetry; Humans; Illicit Drugs; Nanostructures; Serum Albumin, Bovine |
顯示於: | 化學系 |
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