https://scholars.lib.ntu.edu.tw/handle/123456789/543719
標題: | Stathmin immunoreactivity in phaeochromocytomas and paragangliomas: Differential expression between benign and malignant neoplasms | 作者: | WEI-CHOU LIN Chen S.-C. Chuang Y.-T. Kuo K.-L. KUO-HOW HUANG |
公開日期: | 2011 | 卷: | 34 | 期: | 1 | 起(迄)頁: | 15-22 | 來源出版物: | Asian Journal of Surgery | 摘要: | OBJECTIVE: This study aimed to assess stathmin expression in benign and malignant phaeochromocytomas and paragangliomas. METHODS: Tissue specimens from 37 patients with malignant phaeochromocytomas (n = 5), malignant paragangliomas (n = 3), benign phaeochromocytomas (n = 24), and benign paragangliomas (n = 5) were analysed for stathmin expression by western blotting and immunohistochemical staining with polyclonal antibodies. Malignancy was defined by metastases in nonchromaffin tissues. RESULTS: There were higher stathmin expression levels in phaeochromocytomas compared to normal adrenal tissue, by western blotting and reverse-transcriptase polymerase chain reaction, whereas immunohistochemical staining showed stathmin immunoreactivity in the cytoplasm of tumour cells. Malignant neoplasms had significantly higher stathmin expression compared to benign neoplasms by western blotting and immunohistochemical staining. CONCLUSION: Malignant phaeochromocytomas and paragangliomas have significantly higher levels of stathmin expression compared to benign tumours. The potential value of stathmin in predicting malignancies requires further studies. ? 2011 Asian Surgical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955367058&doi=10.1016%2fS1015-9584%2811%2960013-4&partnerID=40&md5=6757666c6b0dce852612f6897410161e https://scholars.lib.ntu.edu.tw/handle/123456789/543719 |
ISSN: | 1015-9584 | DOI: | 10.1016/S1015-9584(11)60013-4 | SDG/關鍵字: | stathmin; tumor marker; adolescent; adrenal disease; adrenal gland; adrenal tumor; adult; article; cancer invasion; differential diagnosis; enzyme immunoassay; female; follow up; human; male; middle aged; paraganglioma; pathology; pheochromocytoma; reverse transcription polymerase chain reaction; Western blotting; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Blotting, Western; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasm Invasiveness; Paraganglioma; Pheochromocytoma; Reverse Transcriptase Polymerase Chain Reaction; Stathmin; Tumor Markers, Biological; Young Adult |
顯示於: | 醫學系 |
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