https://scholars.lib.ntu.edu.tw/handle/123456789/543732
標題: | An audit of nephroureterectomy for upper tract urothelial carcinoma | 作者: | CHAO-YUAN HUANG Chung S.-D. SHUO-MENG WANG Liao C.-H. Lai M.-K. KUO-HOW HUANG YEONG-SHIAU PU SHIH-CHIEH CHUEH HONG-JENG YU |
公開日期: | 2009 | 卷: | 35 | 期: | 12 | 起(迄)頁: | 1333-1336 | 來源出版物: | European Journal of Surgical Oncology | 摘要: | Background: The boundary of nephroureterctomy has been revisited and lymph node dissection has been recommended recently. We investigated the role of synchronous ipsilateral adrenalectomy in treating patients with upper tract urothelial carcinoma. Methods: 110 patients with clinically localized upper tract urothelial carcinoma treated by nephroureterectomy and bladder cuff resection were retrospectively evaluated. 70 patients underwent nephroureterectomy without concomitant ipsilateral adrenalectomy, whereas nephroureterectomy and ipsilateral adrenalectomy was performed in other 40 patients. Cancer specific, metastasis and local recurrence free survival during a follow-up of median 46 months were analyzed. Results: No patient had adrenal metastasis among the 40 adrenalectomized patients. A total of 4 patients developed local recurrences; including 1 of the 70 adrenalectomy-sparing and 3 of the 40 adrenalectomized patients (p?=?0.102, chi-square test). Five patients with adrenalectomy and four without adrenalectomy had distant metastases (p?=?0.212, chi-square test). The five-year local recurrence free survival (p?=?0.09, log-rank test), metastasis-free survival (p?=?0.292, log-rank test), and cancer-specific survival (p?=?0.117, log-rank test) did not have significant difference between both groups. Conclusions: This is the only study in recent 2 decades to evaluate the necessity of synchronous adrenalectomy in treating localized upper tract urothelial carcinoma. Adrenal-sparing nephroureterectomy seems justified for clinically localized upper tract urothelial carcinoma. ? 2009 Elsevier Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70449529505&doi=10.1016%2fj.ejso.2009.05.010&partnerID=40&md5=edea207ee4be2b94559cb68b6cbe5dec https://scholars.lib.ntu.edu.tw/handle/123456789/543732 |
ISSN: | 0748-7983 | DOI: | 10.1016/j.ejso.2009.05.010 | SDG/關鍵字: | adrenalectomy; adult; aged; article; cancer recurrence; cancer survival; cystectomy; disease free survival; distant metastasis; female; follow up; human; major clinical study; male; medical audit; nephroureterectomy; priority journal; urinary tract carcinoma; Adrenalectomy; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Female; Humans; Male; Medical Audit; Middle Aged; Neoplasm Recurrence, Local; Nephrectomy; Retrospective Studies; Survival Analysis; Treatment Outcome; Ureter; Urinary Bladder Neoplasms |
顯示於: | 醫學系 |
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