https://scholars.lib.ntu.edu.tw/handle/123456789/543850
標題: | Poor clinical outcomes among pneumonia patients with depressive disorder | 作者: | Kao L.-T. SHIH-PING LIU Lin H.-C. Lee H.-C. Tsai M.-C. Chung S.-D. |
公開日期: | 2014 | 出版社: | Public Library of Science | 卷: | 9 | 期: | 12 | 起(迄)頁: | e116436 | 來源出版物: | PLoS ONE | 摘要: | Background: Some studies suggested that psychological stress may be associated with the severity and duration of infectious diseases. In this populationbased study, we investigated associations between depressive disorder (DD) and pneumonia outcomes in Taiwan with a large-scale database from the National Health Insurance.Methods: Our study defined 112,198 patients who were hospitalized with a principal diagnosis of pneumonia. We defined their admission date for treatment of pneumonia as the index date. Subsequently, we selected 2,394 patients with DD within 3 years prior to their index date and 11,970 matched patients without DD. We carried out separate conditional logistic regressions to explore the association of clinical pneumonia treatment outcome (ICU admission, use of mechanical ventilation, acute respiratory failure and in-hospital death) with previously diagnosed DD.Results: Patients with DD had a significantly higher probability of an intensive care unit admission (18.1% vs. 12.9%; p<0.001), need for mechanical ventilation (21.9% vs. 18.1%; p<0.001) and in-hospital death (10.4% vs. 9.0%; p50.025) than patients without DD. The study showed that pneumonia patients with DD were respectively 1.41- (95% CI: 1.25?1.59, p<0.001), 1.28- (95% CI: 1.14?1.43, p<0.001), and 1.17- times (95% CI: 1.01?1.36, p50.039) greater odds of being admitted to the ICU, need for mechanical ventilation, and in-hospital death than patients without DD after adjusting for monthly income, urbanization level, geographic region and Charlson Comorbidity Index score. Conclusions: In conclusion, we found that pneumonia patients with DD were associated with poor treatment outcomes compared to patients without DD. ? 2014 Kao et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920479458&doi=10.1371%2fjournal.pone.0116436&partnerID=40&md5=e30dd5c57a18cc867bf536da3af335a7 https://scholars.lib.ntu.edu.tw/handle/123456789/543850 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0116436 | SDG/關鍵字: | acute respiratory failure; adult; aged; Article; artificial ventilation; Charlson Comorbidity Index; controlled study; depression; female; geography; human; income; intensive care; major clinical study; male; mortality; pneumonia; Taiwan; treatment outcome; urbanization; adolescent; complication; depression; hospitalization; intensive care unit; mental stress; middle aged; pathology; pneumonia; risk factor; severity of illness index; time factor; treatment outcome; Adolescent; Adult; Aged; Depressive Disorder; Female; Hospitalization; Humans; Intensive Care Units; Male; Middle Aged; Pneumonia; Risk Factors; Severity of Illness Index; Stress, Psychological; Time Factors; Treatment Outcome |
顯示於: | 醫學系 |
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