https://scholars.lib.ntu.edu.tw/handle/123456789/544177
標題: | Type 2 diabetes but not metabolic syndrome is associated with an increased risk of lower urinary tract symptoms and erectile dysfunction in men aged <45 years | 作者: | Wang C.C. Chancellor M.B. Lin J.M. Hsieh J.H. HONG-JENG YU |
關鍵字: | Bladder; Diabetes; Erectile dysfunction; Lower urinary tract symptom; Uroflowmetry | 公開日期: | 2010 | 卷: | 105 | 期: | 8 | 起(迄)頁: | 1136-1140 | 來源出版物: | BJU International | 摘要: | Objective To investigate the association of type 2 diabetes mellitus (T2DM) and metabolic syndrome with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in Taiwanese men aged <45 years. Patients, Subjects and Methods Voiding and erectile function in 226 men with T2DM, at one diabetes clinic, and 183 healthy men with normal fasting blood glucose levels, were compared. Participants were evaluated using the International Prostate Symptom Score (IPSS), the five-item version of the International Index of Erectile Function questionnaire (IIEF-5), and measurements of flow rate and postvoid residual urine volume. The association of metabolic syndrome with LUTS and ED was also evaluated. Results The mean (sd, range) age of the patients was 38.9 (6.1, 20-45) years and the mean duration of diabetes was 2.8 (3.1, 0.5-20) years. Compared with controls, men with T2DM had a significantly mean (sd) higher IPSS, of 6.1 (5.8) vs 4.1 (4.6) (P < 0.001), an increased of odds ratio (95% confidence interval) of having moderate to severe LUTS of 1.78 (1.12-2.84) (P = 0.01), greater voiding volume of 376 (177) vs 326 (102) mL (P = 0.04), a worse IIEF-5 score of 17.3 (6.4) vs 20.0 (3.8) (P < 0.001), an increased of odds ratio of having moderate to severe ED of 3.5 (2.1-5.8) (P < 0.001) but a similar maximum flow rate and postvoid residual. The IIEF-5 score was negatively correlated with the IPSS (P < 0.0001, coefficient = -0.23, 0.35-0.11) and glycosylated haemoglobin (P = 0.02, coefficient = -0.14, 0.26-0.01). In all, 156 (69%) patients met the criteria for metabolic syndrome. The mean age, duration of diabetes, glycosylated haemoglobin, IPSS, voided volume, maximum urinary flow rate and IIEF-5 score were similar between patients with and without metabolic syndrome. ConclusionS Men with T2DM and aged <45 years had more LUTS but a similar bladder emptying function than the controls. ED was highly prevalent and was associated with the severity of LUTS. Metabolic syndrome did not aggravate the severity of LUTS, emptying function or ED in the early stage of DM. ? 2009 BJU International. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950270062&doi=10.1111%2fj.1464-410X.2009.08913.x&partnerID=40&md5=993da26d461e2446479692540d472827 https://scholars.lib.ntu.edu.tw/handle/123456789/544177 |
ISSN: | 1464-4096 | DOI: | 10.1111/j.1464-410X.2009.08913.x | SDG/關鍵字: | glucose; glycosylated hemoglobin; insulin; oral antidiabetic agent; adult; article; bladder emptying; controlled study; diet restriction; diet therapy; disease association; disease duration; disease severity; erectile dysfunction; glucose blood level; human; International Prostate Symptom Score; lower urinary tract symptom; major clinical study; male; metabolic syndrome X; micturition; non insulin dependent diabetes mellitus; penis erection; postvoid residual urine volume; prevalence; priority journal; questionnaire; Taiwan; urine flow rate; uroflowmetry; Adult; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Erectile Dysfunction; Humans; Lower Urinary Tract Symptoms; Male; Metabolic Syndrome X; Middle Aged; Risk Factors; Urodynamics; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。