https://scholars.lib.ntu.edu.tw/handle/123456789/544284
標題: | Clinical efficacy of prostate-specific antigen testing in patients with prostate disease | 作者: | HONG-JENG YU Chie W.-C. Hsieh C.-H. Tsai C.-C. Lai M.-K. |
關鍵字: | benign prostatic hyperplasia; prostate-specific antigen; prostatic adenocarcinoma; sensitivity; specificity | 公開日期: | 1996 | 卷: | 95 | 期: | 10 | 起(迄)頁: | 782-788 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Prostate-specific antigen (PSA) has become the most commonly used marker for the detection of prostatic adenocarcinoma (PCa) in recent years. To understand the clinical value of PSA testing in patients with prostate disease, the preoperative serum PSA values of 562 patients who underwent prostatic surgery from April 1993 to December 1995 were correlated with histologic findings in samples taken during surgery. Histopathologic findings revealed 93 cases of PCa and 469 cases of benign prostatic hyperplasia (BPH). Of the 220 patients with a serum PSA level within the normal range (0-4 ng/mL), PCa was diagnosed in six (2.7%) cases. Howewer, among the 342 patients (61%) who had serum PSA > 4.0 ng/mL, BPH was diagnosed in 225 (75%) patients. With a PSA cutoff value of 4.0 ng/mL, the sensitivity, specificity and positive predictive value of PSA in distinguishing PCa from BPH were 94%, 45% and 25%, respectively. Raising the cutoff value to 10 ng/mL enhanced the specificity (76%) and positive predictive value (42%) with a slight compromise in sensitivity (85%). Of the 469 patients with BPH, 255 (54%) had a serum PSA > 4.0 ng/mL and 107 (24%) had a serum PSA > 10.0 ng/mL. Prostate volume, histologically documented prostatic inflammation and history of urinary retention prior to PSA determination may partly explain the abnormal elevation of serum PSA in patients with BPH. Our data confirmed the sensitivity of PSA in the detection of PCa in a country with a low incidence of PCa. However, a considerable proportion of patients with BPH had elevated serum PSA levels caused by factors unrelated to malignancy. Raising the cutoff value of PSA or employing adjunct parameters derived from PSA determination may be helpful in improving the diagnostic efficacy of PSA. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029844190&partnerID=40&md5=8f489bbc6f017ac52502fd253a35371d https://scholars.lib.ntu.edu.tw/handle/123456789/544284 |
ISSN: | 0929-6646 | SDG/關鍵字: | prostate specific antigen; article; diagnostic test; human; major clinical study; male; prostate adenocarcinoma; prostate disease; prostate hypertrophy; Aged; Aged, 80 and over; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Hyperplasia; Prostatic Neoplasms; Retrospective Studies; Sensitivity and Specificity |
顯示於: | 醫學系 |
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