https://scholars.lib.ntu.edu.tw/handle/123456789/544343
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHAO-YUAN HUANG | en_US |
dc.contributor.author | Huang Y.-L. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | Shiue H.-S. | en_US |
dc.contributor.author | Chen W.-J. | en_US |
dc.contributor.author | Chen S.-S. | en_US |
dc.contributor.author | Lin Y.-C. | en_US |
dc.contributor.author | Su C.-T. | en_US |
dc.contributor.author | Hsueh Y.-M. | en_US |
dc.creator | Huang C.-Y.;Huang Y.-L.;Yeong-Shiau Pu;Shiue H.-S.;Chen W.-J.;Chen S.-S.;Lin Y.-C.;Su C.-T.;Hsueh Y.-M. | - |
dc.date.accessioned | 2021-02-02T00:46:14Z | - |
dc.date.available | 2021-02-02T00:46:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0045-6535 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962242765&doi=10.1016%2fj.chemosphere.2016.03.056&partnerID=40&md5=32f7155eb2915626e1432355ec8561f5 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544343 | - |
dc.description.abstract | The association between renal cell carcinoma (RCC) and diabetes mellitus (DM), alcohol consumption, insulin-like growth factor binding protein-3 (IGFBP-3) gene, and arsenic exposure, has been the subject of independent studies. However, few studies have examined the combined effect of these factors on RCC risk. The aim of this study was to examine the association between these risk factors and the odds ratio (OR) of RCC. A hospital-based case-control study was conducted in 398 RCC patients and 756 age- and gender-matched non-cancer controls. Genomic DNA was used to examine the genotype of IRS-1 (Gly972Arg), PI3-K (Met362Ile), IGFBP-3 (A[-202]C), and IGFBP-3 (C[-1590]A) by PCR-RFLP. Profiles of urinary arsenic were measured by high performance liquid chromatography linked with hydride generator and atomic absorption spectrometry. Participants who had never consumed alcohol and who had high total levels of urinary arsenic and DM had a high OR of RCC. IGFBP-3 (A[-202]C) and IGFBP-3 (C[-1590]A) were in linkage disequilibrium. Participants carrying high-risk IGFBP-3 diplotypes A-C/C-C, A-A/A-C, and C-A/C-A had a significantly higher odds ratio (OR) and 95% confidence interval (2.80, 1.91-4.12) of RCC compared to those carrying other IGFBP-3 diplotypes. This is the first study to show that borderline significant interaction of high total levels of urinary arsenic and IGFBP-3 high-risk diplotypes significantly enhanced the OR of RCC. Our data also provide evidence that subjects with more risk factors (e.g., high total levels of urinary arsenic, never consumed alcohol, IGFBP-3 high-risk diplotypes) may experience a higher OR of RCC. ? 2016 Elsevier Ltd. | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Chemosphere | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Absorption spectroscopy; Atomic absorption spectrometry; High performance liquid chromatography; Insulin; Polymerase chain reaction; Proteins; Alcohol consumption; Case-control study; Confidence interval; Diabetes mellitus; IGFBP-3; Insulin-like growth factor binding proteins; Linkage disequilibrium; Renal cell carcinoma; Arsenic; arsenic; genomic DNA; insulin receptor substrate 1; phosphatidylinositol 3 kinase; somatomedin binding protein 3; arsenic; IGFBP3 protein, human; somatomedin binding protein 3; absorption; alcohol; arsenic; cells and cell components; confidence interval; diabetes; DNA; genome; genotype; liquid chromatography; protein; adult; alcohol consumption; Article; atomic absorption spectrometry; cancer risk; case control study; controlled study; diabetes mellitus; drinking behavior; female; genotype; high performance liquid chromatography; hospital based case control study; human; hypertension; kidney carcinoma; major clinical study; male; middle aged; polymerase chain reaction; restriction fragment length polymorphism; smoking; urinalysis; chemically induced; genetic predisposition; genetics; genotype environment interaction; kidney carcinoma; kidney tumor; odds ratio; risk factor; Arsenic; Carcinoma, Renal Cell; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Insulin-Like Growth Factor Binding Protein 3; Kidney Neoplasms; Male; Middle Aged; Odds Ratio; Risk Factors; Spectrophotometry, Atomic | - |
dc.title | The joint effects of arsenic and risk diplotypes of insulin-like growth factor binding protein-3 in renal cell carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.chemosphere.2016.03.056 | - |
dc.identifier.pmid | 27038904 | - |
dc.identifier.scopus | 2-s2.0-84962242765 | - |
dc.relation.pages | 90-98 | - |
dc.relation.journalvolume | 154 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.orcid | 0000-0002-9322-6062 | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
Appears in Collections: | 醫學系 |
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