https://scholars.lib.ntu.edu.tw/handle/123456789/544387
標題: | Polymorphism of inflammatory genes and arsenic methylation capacity are associated with urothelial carcinoma | 作者: | Wu C.-C. Huang Y.-K. Chung C.-J. CHAO-YUAN HUANG YEONG-SHIAU PU Shiue H.-S. Lai L.-A. Lin Y.-C. Su C.-T. Hsueh Y.-M. |
公開日期: | 2013 | 卷: | 272 | 期: | 1 | 起(迄)頁: | 30-36 | 來源出版物: | Toxicology and Applied Pharmacology | 摘要: | Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). TNF-α, IL-6 and IL-8 have been shown to be involved in the development and progression of various cancers, including bladder cancer. This study aimed to investigate the joint effect of the polymorphism of TNF-α 308 G/A, IL-6 174 G/C., IL-8 251 T/A and urinary arsenic profiles on urothelial carcinoma (UC) risk. This study evaluated 300 pathologically-confirmed cases of UC and 594 cancer-free controls. Urinary arsenic species were detected using high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. The polymorphism of TNF-α 308 G/A, IL-6 174 G/C and IL-8 251 T/A was determined using polymerase chain reaction-restriction fragment length polymorphism. The joint effects on UC risk were estimated by odds ratios and 95% confidence intervals using unconditional logistic regression. We found that the TNF-α 308 A/A and IL-8 251 T/T polymorphisms were significantly associated with UC. Moreover, significant dose-response joint effect of TNF-α 308 A/A or IL-8 251 T/T genotypes and arsenic methylation indices were seen to affect UC risk. The present results also showed a significant increase in UC risk in subjects with the IL-8 251 T/T genotype for each SD increase in urinary total arsenic and MMA%. In contrast, a significant decrease in UC risk was found in subjects who carried the IL-8 251 T/T genotype for each SD increase in DMA%. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84882772877&doi=10.1016%2fj.taap.2013.05.019&partnerID=40&md5=9357ee374a2ab77a202cd2e32e26eea7 https://scholars.lib.ntu.edu.tw/handle/123456789/544387 |
ISSN: | 0041-008X | DOI: | 10.1016/j.taap.2013.05.019 | SDG/關鍵字: | arsenic; interleukin 6; interleukin 8; tumor necrosis factor alpha; adult; alcohol consumption; article; controlled study; DNA polymorphism; female; gene frequency; genetic association; genotype; hospital based case control study; human; long term exposure; major clinical study; male; methylation; promoter region; risk factor; smoking; transcription initiation; transitional cell carcinoma; urine level; Arsenic; Arsenic methylation capacity; IL-8; TNF-α; Urothelial carcinoma; Aged; Arsenicals; Carcinoma, Transitional Cell; Case-Control Studies; Dose-Response Relationship, Drug; Female; Genotype; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Methylation; Middle Aged; Polymorphism, Genetic; Questionnaires; Regression Analysis; Risk; Socioeconomic Factors; Tumor Necrosis Factor-alpha; Urologic Neoplasms |
顯示於: | 醫學系 |
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