https://scholars.lib.ntu.edu.tw/handle/123456789/544405
標題: | Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure | 作者: | CHAO-YUAN HUANG Su C.-T. Chung C.-J. YEONG-SHIAU PU Chu J.-S. Yang H.-Y. Wu C.-C. Hsueh Y.-M. |
公開日期: | 2012 | 卷: | 262 | 期: | 3 | 起(迄)頁: | 349-354 | 來源出版物: | Toxicology and Applied Pharmacology | 摘要: | 8-Hydroxydeoxyguanosine (8-OHdG) is one of the most reliable and abundant markers of DNA damage. The study was designed to explore the relationship between urinary 8-OHdG and renal cell carcinoma (RCC) and to investigate whether individuals with a high level of 8-OHdG would have a modified odds ratio (OR) of arsenic-related RCC. This case-control study was conducted with 132 RCC patients and 245 age- and sex-matched controls from a hospital-based pool between November 2006 and May 2009. Pathological verification of RCC was completed by image-guided biopsy or surgical resection of renal tumors. Urinary 8-OHdG levels were determined using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Concentrations of urinary arsenic species, including inorganic arsenic, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), were determined by a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Level of urinary 8-OHdG was significantly associated with the OR of RCC in a dose-response relationship after multivariate adjustment. Urinary 8-OHdG was significantly related to urinary total arsenic. The greatest OR (3.50) was seen in the individuals with high urinary 8-OHdG and high urinary total arsenic. A trend test indicated that the OR of RCC was increased with one of these factors and was further increased with both (p=0.002). In conclusion, higher urinary 8-OHdG was a strong predictor of the RCC. High levels of 8-OHdG combined with urinary total arsenic might be indicative of arsenic-induced RCC. ? 2012 Elsevier Inc.. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863853447&doi=10.1016%2fj.taap.2012.05.013&partnerID=40&md5=a9eb6b3cfbd9814e2f1e4628e1573502 https://scholars.lib.ntu.edu.tw/handle/123456789/544405 |
ISSN: | 0041-008X | DOI: | 10.1016/j.taap.2012.05.013 | SDG/關鍵字: | 8 hydroxydeoxyguanosine; arsenic; arsenic acid; arsenic trioxide; cacodylic acid; methanearsonic acid; adult; arsenic poisoning; article; atomic absorption spectrometry; cancer patient; cancer risk; cancer surgery; controlled study; female; high performance liquid chromatography; hospital based case control study; human; kidney biopsy; kidney carcinoma; kidney tumor; liquid chromatography; major clinical study; male; multivariate analysis; risk; tandem mass spectrometry; tumor biopsy; urine level; Age Factors; Arsenic; Carcinoma, Renal Cell; Case-Control Studies; Chromatography, Liquid; Creatinine; Deoxyguanosine; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Odds Ratio; Sex Factors; Taiwan; Tandem Mass Spectrometry |
顯示於: | 醫學系 |
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