https://scholars.lib.ntu.edu.tw/handle/123456789/544405
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHAO-YUAN HUANG | en_US |
dc.contributor.author | Su C.-T. | en_US |
dc.contributor.author | Chung C.-J. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | Chu J.-S. | en_US |
dc.contributor.author | Yang H.-Y. | en_US |
dc.contributor.author | Wu C.-C. | en_US |
dc.contributor.author | Hsueh Y.-M. | en_US |
dc.creator | Huang C.-Y.;Su C.-T.;Chung C.-J.;Yeong-Shiau Pu;Chu J.-S.;Yang H.-Y.;Wu C.-C.;Hsueh Y.-M. | - |
dc.date.accessioned | 2021-02-02T00:46:35Z | - |
dc.date.available | 2021-02-02T00:46:35Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863853447&doi=10.1016%2fj.taap.2012.05.013&partnerID=40&md5=a9eb6b3cfbd9814e2f1e4628e1573502 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544405 | - |
dc.description.abstract | 8-Hydroxydeoxyguanosine (8-OHdG) is one of the most reliable and abundant markers of DNA damage. The study was designed to explore the relationship between urinary 8-OHdG and renal cell carcinoma (RCC) and to investigate whether individuals with a high level of 8-OHdG would have a modified odds ratio (OR) of arsenic-related RCC. This case-control study was conducted with 132 RCC patients and 245 age- and sex-matched controls from a hospital-based pool between November 2006 and May 2009. Pathological verification of RCC was completed by image-guided biopsy or surgical resection of renal tumors. Urinary 8-OHdG levels were determined using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Concentrations of urinary arsenic species, including inorganic arsenic, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), were determined by a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Level of urinary 8-OHdG was significantly associated with the OR of RCC in a dose-response relationship after multivariate adjustment. Urinary 8-OHdG was significantly related to urinary total arsenic. The greatest OR (3.50) was seen in the individuals with high urinary 8-OHdG and high urinary total arsenic. A trend test indicated that the OR of RCC was increased with one of these factors and was further increased with both (p=0.002). In conclusion, higher urinary 8-OHdG was a strong predictor of the RCC. High levels of 8-OHdG combined with urinary total arsenic might be indicative of arsenic-induced RCC. ? 2012 Elsevier Inc.. | - |
dc.relation.ispartof | Toxicology and Applied Pharmacology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 8 hydroxydeoxyguanosine; arsenic; arsenic acid; arsenic trioxide; cacodylic acid; methanearsonic acid; adult; arsenic poisoning; article; atomic absorption spectrometry; cancer patient; cancer risk; cancer surgery; controlled study; female; high performance liquid chromatography; hospital based case control study; human; kidney biopsy; kidney carcinoma; kidney tumor; liquid chromatography; major clinical study; male; multivariate analysis; risk; tandem mass spectrometry; tumor biopsy; urine level; Age Factors; Arsenic; Carcinoma, Renal Cell; Case-Control Studies; Chromatography, Liquid; Creatinine; Deoxyguanosine; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Odds Ratio; Sex Factors; Taiwan; Tandem Mass Spectrometry | - |
dc.title | Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.taap.2012.05.013 | - |
dc.identifier.pmid | 22659136 | - |
dc.identifier.scopus | 2-s2.0-84863853447 | - |
dc.relation.pages | 349-354 | - |
dc.relation.journalvolume | 262 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.orcid | 0000-0002-9322-6062 | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
顯示於: | 醫學系 |
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