https://scholars.lib.ntu.edu.tw/handle/123456789/544418
標題: | Prognostic significance of genetic polymorphisms on prostate-specific antigen recurrence after a radical prostatectomy | 作者: | Tsai Y.-F. Bao B.-Y. Liu C.-C. Huang C.-N. Yu C.-C. Wu T.T. CHAO-YUAN HUANG YEONG-SHIAU PU Chang C.-F. Huang C.-H. Wu W.-J. Huang S.-P. |
公開日期: | 2012 | 出版社: | Elsevier B.V. | 卷: | 23 | 期: | 2 | 起(迄)頁: | 35-41 | 來源出版物: | Urological Science | 摘要: | Approximately one-third of patients with prostate cancer show prostate-specific antigen (PSA) recurrence (biochemical failure) after a radical prostatectomy and are prone to developing metastasis with significant mortality. Although several clinicopathologic indicators, such as the PSA level, Gleason score, pathologic stage, and surgical-margin status, are used to predict outcomes after a curative-intended radical prostatectomy for localized prostate cancer, new biomarkers are still required to improve the prognosis and plan appropriate adjuvant therapy, particularly for patients at high risk of recurrence. DNA-based genetic biomarkers have several advantages over clinicopathologic indicators because they can be preoperatively examined, are easily evaluated, and can be interpreted more objectively without individual bias. In this study, the literature was reviewed from the PubMed database using the keywords " genetic polymorphisms" and " radical prostatectomy" from 1985 to April 2011. The results showed that genetic variants discovered from genome-wide association studies (such as rs1447295, rs1447295, rs6983561, rs13254738, Broad11934905, rs6983267, and rs7000448 at 8q24, rs7920517 and rs10993994 at 10q11, rs10486567 in the . 7JAZF1, rs198977 in the . KLK2, rs9282861 in the . SULT1A1, and rs1536889 in the . TLR4 gene) and single-nucleotide polymorphisms (SNPs) in important pathways (RUNX1, FGFR4, EGFR, VEGF, TNFRSF11B, vitamin D receptor, p53, WNT, inflammatory, androgen synthesis, and metabolism pathways) on prostate cancer occurrence and progression could serve as biomarkers to predict PSA recurrence after a radical prostatectomy. Including the genetic information might improve predictions of PSA recurrence after a radical prostatectomy. Future studies can be dedicated to confirming these findings in other ethnic cohorts and clarifying the roles of these SNPs/genes in the course of prostate cancer progression after a radical prostatectomy through functional analyses. ? 2012 . |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862692078&doi=10.1016%2fj.urols.2012.03.005&partnerID=40&md5=cc36d4279b23667dfc00a9538107e86f https://scholars.lib.ntu.edu.tw/handle/123456789/544418 |
ISSN: | 1879-5226 | DOI: | 10.1016/j.urols.2012.03.005 | SDG/關鍵字: | androgen receptor; cytochrome P450 3A4; epidermal growth factor receptor; fibroblast growth factor receptor 4; interleukin 10; interleukin 6; interleukin 8; osteoprotegerin; prostate specific antigen; protein bcl 2; protein p53; steroid 5alpha reductase 2; transcription factor RUNX1; vasculotropin; vitamin D receptor; Wnt protein; androgen receptor gene; bcl2 gene; cancer growth; cancer prognosis; cytochrome p450 3a4 gene; epidermal growth factor receptor gene; fibroblast growth factor receptor 4 gene; genetic association; genetic marker; genetic polymorphism; genetic variability; human; interleukin 10 gene; interleukin 6 gene; interleukin 8 gene; Mel 18 gene; mutator gene; osteoprotegerin gene; priority journal; prostate cancer; prostatectomy; protein p53 gene; review; signal transduction; single nucleotide polymorphism; steroid 5alpha reductase 2 gene; transcription factor RUNX1 gene; vasculotropin gene; vitamin D receptor gene; WNT gene |
顯示於: | 醫學系 |
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