https://scholars.lib.ntu.edu.tw/handle/123456789/544427
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Cheng J.-H. | en_US |
dc.contributor.author | Huang A.-M. | en_US |
dc.contributor.author | Hour T.-C. | en_US |
dc.contributor.author | Yang S.-C. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | Lin C.-N. | en_US |
dc.creator | Cheng J.-H.;Huang A.-M.;Hour T.-C.;Yang S.-C.;Yeong-Shiau Pu;Lin C.-N. | - |
dc.date.accessioned | 2021-02-02T00:46:41Z | - |
dc.date.available | 2021-02-02T00:46:41Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952283054&doi=10.1016%2fj.ejmech.2011.01.043&partnerID=40&md5=ef3310a78dd5d1820c1d52767d2e67b0 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544427 | - |
dc.description.abstract | In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect. ? 2011 Elsevier Masson SAS. All rights reserved. | - |
dc.relation.ispartof | European Journal of Medicinal Chemistry | - |
dc.subject | Antioxidation; Cytotoxicity; Reactive oxygen species; Xanthone | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid); 3 [3 (4 methylpiperazino)propoxy]xanthone; 3 [3 (cyclohexylamino)propoxy] 6 hydroxyxanthone; 3 [3 (cyclopropylamino)propoxy] 6 hydroxyxanthone; 3 [3 (diethylamino)propoxy] 6 hydroxyxanthone; 3 [3 (diethylamino)propoxy]xanthone; 3 [3 (piperazino)propoxy]xanthone; 3 [3 (piperidin 1 yl)propoxy]xanthone; 3 [3 (pyrrolidin 1 yl)propoxy]xanthone; 3 hydroxy 6 [3 (methylpiperazylamino)propoxy]xanthone; 3 hydroxy 6 [3 (piperazino)propoxy]xanthone; 3 hydroxy 6 [3 (piperidin 1 yl)propoxy]xanthone; 3 hydroxy 6 [3 (pyrrolidin 1 yl)propoxy]xanthone; allopurinol; alpha tocopherol; cisplatin; reactive oxygen metabolite; unclassified drug; xanthine oxidase; xanthone derivative; antioxidant activity; apoptosis; article; cancer cell; cell cycle arrest; cell cycle G1 phase; cell cycle progression; cell death; controlled study; drug cytotoxicity; drug potentiation; drug screening; drug structure; drug synthesis; enzyme inhibition; epithelium cell; human; human cell; IC 50; in vitro study; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cisplatin; DNA Breaks; Dose-Response Relationship, Drug; Drug Discovery; Drug Synergism; Free Radical Scavengers; Humans; Reactive Oxygen Species; Structure-Activity Relationship; Xanthones | - |
dc.title | Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ejmech.2011.01.043 | - |
dc.identifier.pmid | 21345544 | - |
dc.identifier.scopus | 2-s2.0-79952283054 | - |
dc.relation.pages | 1222-1231 | - |
dc.relation.journalvolume | 46 | - |
dc.relation.journalissue | 4 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
顯示於: | 醫學系 |
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