https://scholars.lib.ntu.edu.tw/handle/123456789/544468
標題: | Down-regulated expression of RhoA in human conventional renal cell carcinoma | 作者: | YEONG-SHIAU PU Wang C.-W. Liu G.-Y. Kuo Y.-Z. CHAO YUAN HUANG Kang W.-Y. CHIA-TUNG SHUN CHIA-CHI LIN Wu W.-J. Hour T.-C. |
公開日期: | 2008 | 卷: | 28 | 期: | 4 B | 起(迄)頁: | 2039-2043 | 來源出版物: | Anticancer Research | 摘要: | Background: Renal cell carcinoma (RCC) is the most common cancer in adult kidney. Delayed diagnosis may result in progression and metastasis. Markers for early detection of RCC are lacking. The small GTPase RhoA has been implicated in the regulation of cell morphology, motility and transformation, but the role of RhoA in tumorigenesis of RCC remains unclear. In this study, the significance of RhoA expression in human RCC was characterized. Materials and Methods: RhoA mRNA and protein expressions were examined by real-time polymerase chain reaction (PCR) and immunohistochemistry respectively in 46 pairs of tissues. Results: Real-time PCR revealed that RhoA mRNA expression was significantly lower in cancerous as compared to normal tissues (p=0.036). RhoA protein expression was significantly higher in normal than in cancerous tissues (p=0.032). However, RhoA expression did not correlate with age, differentiation grade or TNM stage (all p>0.05). Conclusion: RhoA down-regulation may be involved in human renal tumorigenesis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-49049084637&partnerID=40&md5=64de8eab5d32c9b392bbf51d57777a72 https://scholars.lib.ntu.edu.tw/handle/123456789/544468 |
ISSN: | 0250-7005 | SDG/關鍵字: | messenger RNA; RhoA guanine nucleotide binding protein; adult; article; carcinogenesis; clinical article; controlled study; down regulation; female; gene expression; human; human tissue; immunohistochemistry; kidney carcinoma; male; priority journal; protein expression; real time polymerase chain reaction; Carcinoma, Renal Cell; Down-Regulation; Female; Humans; Immunohistochemistry; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger |
顯示於: | 醫學系 |
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