https://scholars.lib.ntu.edu.tw/handle/123456789/544474
標題: | Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma | 作者: | Liu C.-H. Huang J.-D. Huang S.-W. Hour T.-C. Huang Y.-K. Hsueh Y.-M. Chiou H.-Y. Lee T.-C. Jan K.-Y. Chen C.-J. YEONG-SHIAU PU |
關鍵字: | Bladder neoplasms; Carcinogenesis; Tobacco; Trinucleotide repeats; Urinary tract | 公開日期: | 2008 | 卷: | 15 | 期: | 2 | 起(迄)頁: | 261-269 | 來源出版物: | Journal of Biomedical Science | 摘要: | The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (<22) repeats, had an elevated risk than those with longer CAG and GGN (OR 4.32 and 4.57, p = 0.034 and 0.042, respectively). However, neither CAG nor GGN affected the UC risk in non-smokers or heavy smokers (?25 packs per day-years). AR CAG polymorphism may affect the risk of UC in both genders. In addition, AR polymorphisms may influence carcinogenic effect of medium-dose of cigarette smoking in men. ? 2007 National Science Council. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-39749143872&doi=10.1007%2fs11373-007-9215-x&partnerID=40&md5=d97a062e38fc8bf2e10491ff5597e3ce https://scholars.lib.ntu.edu.tw/handle/123456789/544474 |
ISSN: | 1021-7770 | DOI: | 10.1007/s11373-007-9215-x | SDG/關鍵字: | androgen receptor; DNA; adult; article; carcinogenic activity; cigarette smoking; comparative study; confidence interval; controlled study; DNA polymorphism; DNA sequence; female; gender; human; leukocyte; major clinical study; male; priority journal; risk; risk factor; sex; smoking habit; statistical significance; structured interview; structured questionnaire; urogenital tract cancer; Nicotiana tabacum |
顯示於: | 醫學系 |
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