https://scholars.lib.ntu.edu.tw/handle/123456789/544508
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | Hour T.-C. | en_US |
dc.contributor.author | Chuang S.-E. | en_US |
dc.contributor.author | ANN-LII CHENG | en_US |
dc.contributor.author | Lai M.-K. | en_US |
dc.contributor.author | Kuo M.-L. | en_US |
dc.creator | Yeong-Shiau Pu;Hour T.-C.;Chuang S.-E.;Cheng A.-L.;Lai M.-K.;Kuo M.-L. | - |
dc.date.accessioned | 2021-02-02T00:47:04Z | - |
dc.date.available | 2021-02-02T00:47:04Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0270-4137 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-2942627100&doi=10.1002%2fpros.20057&partnerID=40&md5=20eaea62cb79f0230e09439afaa36cce | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544508 | - |
dc.description.abstract | BACKGROUND. Interleukin (IL)-6-mediated anti-apoptotic effects and drug-resistance mechanisms in prostate cancer cells were investigated. METHODS. IL-6 levels of PC-3 and LNCaP cells were studied by using ELISA. Protective effects of IL-6 on cytotoxic agent-induced apoptosis were studied by exogenous IL-6 in serum-starved PC-3 cells and by anti-sense IL-6 strategy. Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) were used to determine IL-6 effects on Bcl-2 family proteins. Tetracycline-regulated Bcl-xL expression system and dominant negative STAT3 transfectants were used to study IL-6 signaling pathways and its anti-apoptosis effects. RESULTS. Exogenous IL-6 and anti-sense IL-6 oligonucleotide treatment conferred resistance to cytotoxic agent-induced apoptosis. Among Bcl-2 family proteins, only Bcl-xL was evidently increased by IL-6 stimulation. The anti-apoptotic effect of IL-6 can be significantly attenuated by anti-sense bcl-xL transfection and partially abrogated in dominant negative STAT3 transfectants. CONCLUSIONS. IL-6 is a survival factor against cytotoxic agent-induced apoptosis through both STAT3 and bcl-xL pathways in prostate cancer cells. ? 2004 Wiley-Liss, Inc. | - |
dc.relation.ispartof | Prostate | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antineoplastic agent; complementary DNA; cytotoxic agent; interleukin 6; oligonucleotide; protein bcl 2; protein bcl xl; STAT3 protein; tetracycline; apoptosis; article; cancer cell; cell protection; cell survival; controlled study; drug resistance; drug response; enzyme linked immunosorbent assay; human; human cell; priority journal; prostate cancer; reverse transcription polymerase chain reaction; serum; signal transduction; Western blotting; Acute-Phase Proteins; Apoptosis; bcl-X Protein; Blotting, Western; Cell Survival; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Humans; Interleukin-6; Male; Oligonucleotides, Antisense; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | - |
dc.title | Interleukin-6 is responsible for drug resistance and anti-apoptotic effects in prostatic cancer cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/pros.20057 | - |
dc.identifier.pmid | 15162378 | - |
dc.identifier.scopus | 2-s2.0-2942627100 | - |
dc.relation.pages | 120-129 | - |
dc.relation.journalvolume | 60 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.orcid | 0000-0002-9152-6512 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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