https://scholars.lib.ntu.edu.tw/handle/123456789/545061
標題: | Treatment of constipation in long-term care with chinese herbal formula: A randomized, double-blind placebo-controlled trial | 作者: | Huang C.-H. Su Y.-C. Li T.-C. Lee S.-C. Lin J.-S. TAI-YUAN CHIU Lue H.-C. |
公開日期: | 2011 | 卷: | 17 | 期: | 7 | 起(迄)頁: | 639-646 | 來源出版物: | Journal of Alternative and Complementary Medicine | 摘要: | Objectives: This study is aimed to evaluate the therapeutic efficacy and safety of CCH1, modified from an ancient herbal formula in Traditional Chinese Medicine, for the residents with constipation in long-term care. Methods: In this randomized, double-blind, placebo-controlled trial, 90 residents from three long-term care units were randomized to 8 weeks of treatment with CCH1 or placebo and then the subjects were followed up for an additional 4 weeks. Results: The mean numbers of weekly spontaneous bowel movement in the CCH1 group were greater than in the placebo group during the treatment phase of 8 weeks (p?€?€?0.05); the greatest difference was during weeks 1-4 (6.2±2.2 versus 3.4±2.1, p<0.001). Smaller mean numbers of weekly rectal treatments were observed with CCH1 compared with placebo during weeks 1-8 (p<0.05). The mean numbers of weekly rescue laxative tablets of magnesium oxide were significantly less in the CCH1 group than in the placebo group during the entire 12-week period (p<0.01), with the greatest difference during weeks 5-8 (14.4±16.3 versus 33.4±23.5, p<0.001). No significant safety concerns were noted. Conclusions: The six-herb formula (CCH1), compared with placebo, is effective on the treatment of constipation in long-term care. However, its maintenance effect needs further trial. Comparison of efficacy or cost-effectiveness with current laxatives is encouraged. ? 2011 Mary Ann Liebert, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959827655&doi=10.1089%2facm.2010.0150&partnerID=40&md5=d64d50658a605f1cea92f34e9999c9a3 https://scholars.lib.ntu.edu.tw/handle/123456789/545061 |
ISSN: | 1075-5535 | DOI: | 10.1089/acm.2010.0150 | SDG/關鍵字: | cch1; herbaceous agent; magnesium oxide; unclassified drug; adult; aged; article; Chinese medicine; constipation; controlled study; cost effectiveness analysis; dermatitis; diarrhea; double blind procedure; drug efficacy; drug safety; female; follow up; human; intestine motility; long term care; major clinical study; male; priority journal; randomized controlled trial; resident; Adult; Aged; Aged, 80 and over; Constipation; Defecation; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Laxatives; Long-Term Care; Magnesium Oxide; Male; Middle Aged; Phytotherapy; Young Adult |
顯示於: | 醫學系 |
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