https://scholars.lib.ntu.edu.tw/handle/123456789/545313
標題: | Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus | 作者: | Wu C.-S. CHUNG-YI HU Chan C.-J. Chang S.-K. PING-NING HSU |
公開日期: | 2012 | 卷: | 31 | 期: | 10 | 起(迄)頁: | 1443-1448 | 來源出版物: | Clinical Rheumatology | 摘要: | The growth arrest-specific 6 (GAS6) gene product participates in platelet activation and granulocyte interaction with the endothelium. Our case-control study aimed to determine whether polymorphism of GAS6 was associated with predisposing risk or specific clinical manifestations of systemic lupus erythematosus (SLE). Two of the singlenucleotide polymorphisms (SNPs) of the GAS6 gene, GAS6 834+7G/A (rs8191974) and GAS6 +1332C/T (rs1803628), were investigated in 83 SLE patients and 89 non-lupus control subjects. We demonstrated that among lupus patients, the GAS6 +1332 T allele was more prevalent in patients with cutaneous vasculitis (allele T 41.7% in patients with cutaneous vasculitis compared with 18.3% in patients without vasculitis, odds ratio (OR) 3.2, 95% confidence interval 1.3-8.0, p=0.016). In conclusion, GAS6 polymorphism is positively associated with cutaneous vasculitis in SLE patients, which suggests that GAS6 polymorphism could be a genetic marker for SLE with cutaneous vasculitis. ? Clinical Rheumatology 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872136694&doi=10.1007%2fs10067-012-2027-z&partnerID=40&md5=aa50737513310ab9a96e0b6d787a60c8 https://scholars.lib.ntu.edu.tw/handle/123456789/545313 |
ISSN: | 0770-3198 | DOI: | 10.1007/s10067-012-2027-z | SDG/關鍵字: | growth arrest specific protein 6; adult; allele; article; controlled study; exon; female; gene frequency; genetic association; genetic risk; genetic variability; genotype; human; intron; major clinical study; male; priority journal; single nucleotide polymorphism; systemic lupus erythematosus; vasculitis; Adult; Asian Continental Ancestry Group; Case-Control Studies; Comorbidity; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Intercellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; Male; Middle Aged; Polymorphism, Single Nucleotide; Taiwan; Vasculitis, Leukocytoclastic, Cutaneous |
顯示於: | 醫學系 |
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