https://scholars.lib.ntu.edu.tw/handle/123456789/545332
標題: | The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer | 作者: | Hsu P.-I. Huang M.-S. Chen H.-C. PING-NING HSU Lai T.-C. Wang J.-L. Lo G.-H. Lai K.-H. Tseng C.-J. Hsiao M. |
關鍵字: | ANXA7; Differentiation; Gastric cancer; Metastasis; Prognosis | 公開日期: | 2008 | 卷: | 97 | 期: | 7 | 起(迄)頁: | 609-614 | 來源出版物: | Journal of Surgical Oncology | 摘要: | Background: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated. Methods: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients. Results: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159). Conclusions: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis. ? 2008 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-44849138287&doi=10.1002%2fjso.21046&partnerID=40&md5=08cef380023d87172125f43e9beec107 https://scholars.lib.ntu.edu.tw/handle/123456789/545332 |
ISSN: | 0022-4790 | DOI: | 10.1002/jso.21046 | SDG/關鍵字: | synexin; article; cancer growth; cancer survival; distant metastasis; human; human tissue; immunohistochemistry; Japan; Kaplan Meier method; Lauren classification; major clinical study; metastasis potential; overall survival; priority journal; prognosis; protein expression; statistical analysis; stomach adenocarcinoma; tumor classification; tumor differentiation; tumor suppressor gene; Adenocarcinoma; Adult; Annexin A7; Cell Differentiation; Female; Gene Expression; Humans; Immunohistochemistry; Male; Stomach Neoplasms |
顯示於: | 醫學系 |
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