https://scholars.lib.ntu.edu.tw/handle/123456789/545336
標題: | Association of the Myeloperoxidase polymorphism with the risk of gastric cancer | 作者: | Hsu P.-I. Jwo J.-J. Yang C.-L. PING-NING HSU Yang H.-B. Lai K.-H. Chen I.-S. Chuah S.-K. Wu D.-C. Chen A. |
關鍵字: | Gastric cancer; Gastritis; Helicobacter pylori; Myeloperoxidase; Neutrophil; Polymorphism | 公開日期: | 2008 | 卷: | 28 | 期: | 2 B | 起(迄)頁: | 1317-1323 | 來源出版物: | Anticancer Research | 摘要: | Background: The myeloperoxidase in neutrophils manufactures many bactericidal oxidants. The aim of this study was to clarify the relations between the myeloperoxidase polymorphism and gastric cancer development. Patients and Methods: In a case control study of 157 consecutive gastric cancer patients and 192 controls, the myeloperoxidase -463G→A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System. Results: The carriage of myeloperoxidase allele A, male gender, advanced age, high intake of salty food and Helicobacter pylori infection independently increased the risk of gastric cancer [95% confidence interval (CI): 1.5-5.0, 1.7-6.5, 2.6-8.6, 1.1-2.6 and 1.2-3.8, respectively]. H. pylori-infected individuals who were carriers of myeloperoxidase allele A had increased risks of both intestinal and diffuse types of gastric cancer with odds ratios of 7.9 (95% CI 2.6-23.5) and 8.6 (95% CI 2.0-36.7), respectively. In the H. pylori-infected individuals, allele A carriers displayed higher scores of bacterial density (p=0.02) and neutrophil infiltration (p=0.05) in the antrum and higher scores of neutrophil infiltration (p=0.02) and gland atrophy (p=0.03) in the corpus than did non-carriers. Conclusion: This study verifies the association of myeloperoxidase -463G→A polymorphism with gastric cancer. The mechanisms underlying this genetic polymorphism in developing gastric cancer merit further investigations. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42549101282&partnerID=40&md5=0742acdc4d25865a707bb2d9062f8065 https://scholars.lib.ntu.edu.tw/handle/123456789/545336 |
ISSN: | 0250-7005 | SDG/關鍵字: | myeloperoxidase; aged; allele; article; cancer patient; cancer risk; controlled study; enzyme polymorphism; female; genotype; Helicobacter infection; human; major clinical study; male; neutrophil chemotaxis; priority journal; stomach cancer; stomach mucosa; Aged; Case-Control Studies; Female; Gastritis; Genetic Predisposition to Disease; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Peroxidase; Polymorphism, Single Nucleotide; Stomach Neoplasms |
顯示於: | 醫學系 |
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