https://scholars.lib.ntu.edu.tw/handle/123456789/545791
標題: | Tissue hepatocyte growth factor and proliferating cell nuclear antigen in hepatocellular carcinoma | 作者: | GUAN-TARN HUANG Lee, Hsuan-Shu Chen C.-H. Chiou L.-L. Lee, Cha-Ze DING-SHINN CHEN Hsu H.-C. JIN-CHUAN SHEU |
公開日期: | 1999 | 卷: | 98 | 期: | 2 | 起(迄)頁: | 92-96 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | To better understand the roles of hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) in hepatocellular carcinoma (HCC), 37 surgically resected HCCs and corresponding nontumorous liver tissue specimens were collected and the expression of these two factors was quantified by Western blot analysis. Both HGF and PCNA expression levels were significantly higher in tumor tissue than in nontumorous liver tissue. However, their expression levels in HCC tissue and nontumorous tissue did not show any significant correlation with the recurrence of HCC. In addition, HGF and PCNA did not correlate with Edmondson's grade, invasiveness of tumor, presence of tumor capsule, or tumor size. No correlation was found between the expression levels of HGF and PCNA in HCC tissue. We conclude that, although both HGF and PCNA are present at higher levels in HCC tissue than in nontumorous liver tissue, they play little role in the clinicopathologic manifestations of this tumor. HGF appears to contribute little, if at all, to the proliferative activity of HCC cells. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033062608&partnerID=40&md5=3b22cba71e757a86fe8730395e8080a5 https://scholars.lib.ntu.edu.tw/handle/123456789/545791 |
ISSN: | 0929-6646 | SDG/關鍵字: | cycline; scatter factor; adult; aged; article; cancer grading; cancer invasion; cancer recurrence; clinical article; controlled study; disease association; encapsulation; female; human; human tissue; liver cell carcinoma; male; pathophysiology; protein determination; protein expression; tumor volume; Adult; Aged; Carcinoma, Hepatocellular; Female; Hepatocyte Growth Factor; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Proliferating Cell Nuclear Antigen |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。