https://scholars.lib.ntu.edu.tw/handle/123456789/545794
標題: | Clinical impact of screening first-degree relatives of patients with hepatocellular carcinoma | 作者: | CHIEN-HUNG CHEN GUAN-TARN HUANG Lee, Hsuan-Shu PEI-MING YANG DING-SHINN CHEN JIN-CHUAN SHEU |
公開日期: | 1998 | 卷: | 27 | 期: | 3 | 起(迄)頁: | 236-239 | 來源出版物: | Journal of Clinical Gastroenterology | 摘要: | Family history is a risk factor for hepatocellular carcinoma (HCC). However, the risk of first-degree relatives is not known. To investigate the risk of HCC among the first-degree relatives of probands and whether screening can lead to early diagnosis of HCCs in these relatives, we conducted a screening program. The probands' first-degree relatives who were >20 years old were included. Serum aminotransferase, hepatitis viral marker, α-fetoprotein, and abdominal sonography were done. HCCs were found in 20 (1.9%) of the 1,046 first-degree relatives, especially in the male siblings. Eighty-five percent of these 20 HCC patients were hepatitis B virus carriers. Forty percent of these 20 HCC patients had tumors <5 cm. Approximately 55% of these 20 HCCs were resectable. The 1-year survival rate in these 20 HCC patients with resectable HCCs was 72.7%. However, the overall 1-year survival rate was only 40%. We found HCC in 1.9% of the first-degree relatives of HCC patients. The male relatives, especially the older brothers, were the group at highest risk. The familial HCCs were closely related to the hepatitis B virus infection. To detect HCCs early, initial screening should be done as early as possible on the HCC family members. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031732412&doi=10.1097%2f00004836-199810000-00011&partnerID=40&md5=ec6552e9b22f0f328e72423ce2d1d3c3 https://scholars.lib.ntu.edu.tw/handle/123456789/545794 |
ISSN: | 0192-0790 | DOI: | 10.1097/00004836-199810000-00011 | SDG/關鍵字: | adult; aged; article; cancer risk; cancer screening; cancer survival; female; hepatitis b virus; human; liver cell carcinoma; major clinical study; male; priority journal; relative; sex difference; virus carrier; Adult; Aged; Carcinoma, Hepatocellular; Carrier State; Female; Genetic Predisposition to Disease; Genetic Screening; Hepatitis B, Chronic; Humans; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Risk Factors; Survival Rate; Ultrasonography |
顯示於: | 醫學系 |
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