https://scholars.lib.ntu.edu.tw/handle/123456789/545807
標題: | Multiple hepatocellular carcinomas at the early stage have different clonality | 作者: | JIN-CHUAN SHEU GUAN-TARN HUANG Chou H.-C. PO-HUANG LEE Wang, Jin-Town Lee, Hsuan-Shu DING-SHINN CHEN |
公開日期: | 1993 | 卷: | 105 | 期: | 5 | 起(迄)頁: | 1471-1476 | 來源出版物: | Gastroenterology | 摘要: | Background: The clonality of hepatocellular carcinoma is still controversial. To evaluate the clonality of this cancer, mostly small multiple hepatocellular carcinomas of 18 patients were analyzed by DNA finger-printing. Methods: DNA from the liver tissues was digested with Hinfl. After gel electrophoresis, in gel-hybridization with a synthetic oligonucleotide probe GTGGTGGTGGTGGTG was performed. The band patterns were compared among the tumors and the nontumor part. In patients positive for hepatitis B surface antigen (HBsAg), the Integration pattern of hepatitis B viral DNA in liver tissues was also analyzed. Results: Seven of the 9 HBsAg-positive patients had tumors with different clonalitles by both methods. In the remaining 9 HBsAg-negative patients, 4 had different band patterns in their tumors by DNA fingerprinting. Conclusions: Multiple hepatocellular carcinomas frequently have different clonalitles; this finding reiterates the importance of eliminating the underlying cause and the contributing factors of hepatocarcinogenesis. ? 1992. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027358775&doi=10.1016%2f0016-5085%2893%2990153-4&partnerID=40&md5=6394592a12604cb1362c615b8da92ee2 https://scholars.lib.ntu.edu.tw/handle/123456789/545807 |
ISSN: | 0016-5085 | DOI: | 10.1016/0016-5085(93)90153-4 | SDG/關鍵字: | cell dna; hepatitis b surface antigen; virus dna; adult; article; clinical article; clonogenesis; dna fingerprinting; female; hepatitis b; hepatitis b virus; hepatitis c virus; human; human tissue; liver carcinogenesis; liver cell carcinoma; male; priority journal; Adult; Aged; Base Sequence; Carcinoma, Hepatocellular; Clone Cells; DNA Fingerprinting; DNA, Neoplasm; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis B Virus; Human; Liver; Liver Neoplasms; Male; Middle Age; Molecular Sequence Data; Support, Non-U.S. Gov't |
顯示於: | 醫學系 |
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