https://scholars.lib.ntu.edu.tw/handle/123456789/545855
標題: | Correlation of HBV DNA levels in serum and liver of chronic hepatitis B patients with cirrhosis | 作者: | Lee, Cha-Ze GUAN-TARN HUANG PEI-MING YANG JIN-CHUAN SHEU Lai M.Y. DING-SHINN CHEN |
公開日期: | 2002 | 卷: | 22 | 期: | 2 | 起(迄)頁: | 130-135 | 來源出版物: | Liver | 摘要: | Aim: We sought to evaluate whether serum HBV DNA levels correlates with the liver free HBV DNA levels in chronic hepatitis B. Methods: Thirty-three consecutive chronic hepatitis B patients with cirrhosis were included in this study. Twenty cases had detectable serum HBV DNA (> 1.8 pg/ml). All had detectable free liver HBV DNA. Results: There was a strong correlation between the serum and liver HBV DNA levels (P = 0.0018, r = 0.717). Thirteen cases had undetectable serum HBV DNA. Among them, six cases still had detectable liver free HBV DNA. Eight cases were HBeAg-positive. Among them, seven cases were positive for both serum and liver HBV DNA, and one case was negative for both serum and liver HBV DNA. Twenty-five cases were HBeAg-negative and anti-HBe-positive. Among them, 13 cases were positive for serum HBV DNA, and 19 cases were positive for liver HBV DNA. No significant difference was noted for positivity of serum HBV DNA or liver free HBV DNA between HBeAg-positive and HBeAg-negative groups. The level of serum HBV DNA (491 ± 772 pg/ml versus 203 ± 447 pg/ml, p = 0.07) and liver free HBV DNA (33 ± 81 pg/μg versus 6 ± 15 pg/μg, p = 0.13) was also not statistically different. Conclusion: In conclusion, serum HBV DNA levels is strongly correlated with liver HBV DNA levels in chronic hepatitis B with cirrhosis. Liver free HBV DNA can still be detected in about half of the cirrhotic patients with undetectable serum HBV DNA. Serum HBeAg is not a good predictor of serum or liver HBV DNA levels in cirrhotic patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036271889&doi=10.1034%2fj.1600-0676.2002.01525.x&partnerID=40&md5=b29c21a8ff0a9a88c3bd6eb65c868f90 https://scholars.lib.ntu.edu.tw/handle/123456789/545855 |
ISSN: | 0106-9543 | DOI: | 10.1034/j.1600-0676.2002.01525.x | SDG/關鍵字: | hepatitis B(e) antibody; hepatitis B(e) antigen; virus DNA; article; blood level; clinical article; controlled study; correlation analysis; DNA extraction; hepatitis B; Hepatitis B virus; human; human cell; human tissue; liver biopsy; liver cirrhosis; liver level; prediction; Southern blotting; Biological Markers; DNA, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Polymerase Chain Reaction |
顯示於: | 醫學系 |
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