https://scholars.lib.ntu.edu.tw/handle/123456789/546320
標題: | Quality of life in polyneuropathy: Association with biomarkers of small fiber impairment | 作者: | MENG-TING LIN Lee L.J.-H. CHI-CHAO CHAO SUNG-TSANG HSIEH |
公開日期: | 2015 | 出版社: | BioMed Central | 卷: | 13 | 期: | 1 | 起(迄)頁: | 169 | 來源出版物: | Health and Quality of Life Outcomes | 摘要: | Background: Polyneuropathy presumably lowers quality of life (QoL). However, there is a lack of systematic studies that assess QoL changes and biomarkers of polyneuropathy as determinants of QoL. We aimed to investigate the relationship between every specific aspect of QoL and the clinical parameters used to assess the impairment of motor, sensory (large and small fibers), and autonomic nerves in polyneuropathy. Methods: Polyneuropathy patients were recruited from September 2013 to March 2014; QoL was assessed using (1) the WHO Quality of Life-BREF (WHOQoL), (2) the European Quality of Life-5 Dimensions, and (3) the Brief Pain Inventory Short Form. Neuropathy examinations included nerve conduction studies, autonomic function tests, quantitative sensory testing (QST), and intraepidermal nerve fiber (IENF) density assessment of skin biopsies. Results: There were 61 polyneuropathy patients (male/female = 38/23, mean age 58.14 ± 12.95 years). Patients had a lower QoL than age-and gender-matched controls in the physical and psychological domains of the WHOQoL. Among the biomarkers for different nerve fiber categories, only the small fiber neuropathy assessments were significantly related to all domains of the WHOQoL. In contrast, the parameters of the large fiber neuropathy were independent of QoL. Patients with abnormal temperature thresholds and a lower IENF density had lower WHOQoL scores compared to patients with normal thresholds and IENF densities. Warm threshold of the foot in QST was linearly correlated with all domains of the WHOQoL. Conclusions: QoL scores were reduced in polyneuropathy, and biomarkers of small fiber neuropathy, i.e., warm threshold and IENF density were discriminating predictors of QoL. ? 2015 Lin et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944403899&doi=10.1186%2fs12955-015-0363-9&partnerID=40&md5=d12566798dfbc6bce42aae729800b85f https://scholars.lib.ntu.edu.tw/handle/123456789/546320 |
ISSN: | 1477-7525 | DOI: | 10.1186/s12955-015-0363-9 | SDG/關鍵字: | adult; anxiety; Article; autonomic nerve; autonomic nervous system; Brief Pain Inventory; controlled study; depression; female; human; laboratory test; major clinical study; male; motor dysfunction; muscle strength; nerve conduction; nerve fiber; neurologic examination; physical activity; polyneuropathy; prick test; psychological aspect; quality of life; scoring system; sensory nerve; skin biopsy; small fiber neuropathy; Taiwan; world health organization; aged; evaluation study; methodology; middle aged; pain measurement; peripheral neuropathy; physiology; polyneuropathy; psychology; psychomotor performance; quality of life; biological marker; Adult; Aged; Biomarkers; Female; Humans; Male; Middle Aged; Nerve Fibers; Neurologic Examination; Pain Measurement; Peripheral Nervous System Diseases; Polyneuropathies; Psychomotor Performance; Quality of Life; Research Design |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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