https://scholars.lib.ntu.edu.tw/handle/123456789/546853
標題: | A Multifunctional Microfluidic Device for Blood Typing and Primary Screening of Blood Diseases | 作者: | Lin, J.-H. Tsai, T.-T. Zeng, Q. Chang, C.-Y. Guo, J.-Y. Lin, C.-J. CHIEN-FU CHEN |
關鍵字: | anemia; blood agglutination test; blood typing; point-of-care diagnosis; polycythemia | 公開日期: | 2020 | 卷: | 5 | 期: | 10 | 起(迄)頁: | 3082-3090 | 來源出版物: | ACS Sensors | 摘要: | In this work, we demonstrate a multifunctional, portable, and disposable microfluidic device for blood typing and primary screening of blood diseases. Preloaded antibodies (anti-A, anti-B, and anti-D) interact with injected whole blood cells to cause an agglutination reaction that blocks a microslit in the microfluidic channel to accumulate red blood cells and form a visible red line that can be easily read to determine the blood type. Moreover, the different blood density and agglutination properties of normal and subtype blood groups, as well as different blood diseases, including anemia and polycythemia vera, generate different lengths of blood agglutination within the channels, which allows us to successfully screen these various conditions in as little as 2 min. The required blood volume for each test is just 1 μL, which can be obtained by minimally invasive finger pricking. This novel method of observing agglutinated red blood cells to distinguish blood types and diseases is both feasible and affordable, suggesting its promise for use in areas with limited resources. ? |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85094219906&partnerID=40&md5=da73e4fdb66caf018967314af257bb74 https://scholars.lib.ntu.edu.tw/handle/123456789/546853 |
DOI: | 10.1021/acssensors.0c00969 | SDG/關鍵字: | Antigen-antibody reactions; Bacteria; Cells; Diagnosis; Fluidic devices; Microfluidics; Blood typing; Blood volumes; Micro-fluidic devices; Microfluidic channel; Minimally invasive; Polycythemia vera; Primary screening; Red blood cell; Blood; antigen antibody reaction; blood group typing; hematologic disease; human; lab on a chip; microfluidics; Agglutination; Blood Grouping and Crossmatching; Hematologic Diseases; Humans; Lab-On-A-Chip Devices; Microfluidics |
顯示於: | 應用力學研究所 |
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