https://scholars.lib.ntu.edu.tw/handle/123456789/547061
標題: | Magnetite-based nanomedicine for cancer diagnosis and therapy using loco-regional hyperthermia combined with chemotherapy | 作者: | Yang, S.-J. Tseng, S.-Y. Wang, C.-H. Young, T.-H. Shieh, M.-J. MING-JIUM SHIEH TAI-HORNG YOUNG |
公開日期: | 2019 | 來源出版物: | World Congress on Recent Advances in Nanotechnology | 摘要: | Colorectal cancer is now one of the major diseases in the world. With westernized diet in Taiwan, the incidence of colorectal cancer increases. For cancer stem cell therapy, CD133 (prominin-1) is a theoretical cancer stem cell (CSC) marker for colorectal cancer and is a proposed therapeutic target. Cells with CD133 overexpression have demonstrated enhanced tumor-initiating ability and tumor relapse probability [1-6]. To resolve the problem of chemotherapy failure, we will develop a magnetite-based nanomedicine using loco-regional hyperthermia combined with chemotherapy. The targeting carrier has a magnetite nanoparticle (superparamagnetic iron oxide nanoparticles, SPIO) core and a layer-by-layer polyelectrolyte molecule shell that carries irinotecan (CPT-11) and anti-human prominin-1 (PROM1/CD133) monoclonal antibody for cancer stem cell-specific targeting. Besides as a contrast agent for MRI, this nanomedicine plays as an important role to relay the externally delivered radiofrequency energy for tumor hyperthermia [7,8]. Locoregional heat can trigger a drug release from the carrier as it directly damages tumor cells and cancer stem cells.. Finally, the use of this nanomedicine can improve the half-life of chemotherapy drugs in the blood and reduce the side effect, and is significantly more efficacious than hyperthermia or chemotherapy alone for colorectal cancer therapy. ? 2019, Avestia Publishing. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85087049744&partnerID=40&md5=ceb8cbb1dc519d28d886688b91e4327f https://scholars.lib.ntu.edu.tw/handle/123456789/547061 |
DOI: | 10.11159/icnnfc19.112 |
顯示於: | 醫學系 |
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